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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 154 - 161 (8page)
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Background: Mesenchymal stem cells (MSCs) attenuate injury in various lung injury models through paracrine effects. We hypothesized that intratracheal transplantation of allogenic MSCs could attenuate lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice, mediated by anti-inflammatory responses. Methods: Six-week-old male mice were randomized to either the control or the ALI group. ALI was induced by intratracheal LPS instillation. Four hours after LPS instillation, MSCs or phosphate-buffered saline was randomly intratracheally administered. Neutrophil count and protein concentration in bronchoalveolar lavage fluid (BALF); lung histology; levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and macrophage inflammatory protein-2; and the expression of proliferation cell nuclear antigen (PCNA), caspase-3, and caspase-9 were evaluated at 48 hours after injury. Results: Treatment with MSCs attenuated lung injury in ALI mice by decreasing protein level and neutrophil recruitment into the BALF and improving the histologic change. MSCs also decreased the protein levels of proinflammatory cytokines including IL-1β, IL-6, and TNF-α, but had little effect on the protein expression of PCNA, caspase-3, and caspase-9. Conclusions: Intratracheal injection of bone marrow-derived allogenic MSCs attenuates LPSinduced ALI via immunomodulatory effects.
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참고문헌 (34)
참고문헌 신청
Rubenfeld GD / 2005 / Incidence and outcomes of acute lung injury / N Engl J Med 353:1685~1693
Bellani G / 2016 / Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries / JAMA 315:788~800
Zambon M / 2008 / Mortality rates for patients with acute lung injury/ARDS have decreased over time / Chest 133:1120~1127
Amato MB / 1998 / Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome / N Engl J Med 338:347~354
Guerin C / 2013 / Prone positioning in severe acute respiratory distress syndrome / N Engl J Med 368:2159~2168
Bellani G / 2016 / Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries / JAMA 315:788~800
Zambon M / 2008 / Mortality rates for patients with acute lung injury/ARDS have decreased over time / Chest 133:1120~1127
Amato MB / 1998 / Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome / N Engl J Med 338:347~354
Guerin C / 2013 / Prone positioning in severe acute respiratory distress syndrome / N Engl J Med 368:2159~2168
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