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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 154 - 163 (10page)
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초록· 키워드
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Background: Acute respiratory distress syndrome (ARDS) remains a life-threatening disease. Many patients with ARDS do not recover fully, and progress to terminal lung fibrosis. Angiotensin-converting enzyme (ACE) inhibitor is known to modulate the neurohormonal system to reduce inflammation and to prevent tissue fibrosis. However, the role of ACE inhibitor in the lungs is not well understood.
We therefore conducted this study to elucidate the effect of renin-angiotensin system (RAS) blockage on the prognosis of patients with ARDS.
Methods: We analyzed medical records of patients who were admitted to the medical intensive care unit (ICU) at a tertiary care hospital from January 2005 to December 2010. ARDS was determined using the Berlin definition. The primary outcome was the mortality rate of ICU. Survival analysis was performed after adjustment using propensity score matching.
Results: A total of 182 patients were included in the study. Thirty-seven patients (20.3%) took ACE inhibitor or angiotensin receptor blocker (ARB) during ICU admission, and 145 (79.7%) did not; both groups showed similar severity scores. In the ICU, mortality was 45.9% in the RAS inhibitor group and 58.6% in the non-RAS inhibitor group (P = 0.166). The RAS inhibitor group required a longer duration of mechanical ventilation (29.5 vs. 19.5, P = 0.013) and longer ICU stay (32.1 vs. 20.2 days, P < 0.001). In survival analysis, the RAS inhibitor group showed better survival rates than the non-RAS group (P < 0.001).
Conclusions: ACE inhibitor or ARB may have beneficial effect on ARDS patients.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Ware LB / 2000 / The acute respiratory distress syndrome / N Engl J Med 342:1334~1349
Bernard GR / 1994 / The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination / Am J Respir Crit Care Med 149(3 Pt 1):818~824
Krafft P / 1996 / The acute respiratory distress syndrome: definitions, severity and clinical outcome. An analysis of 101 clinical investigations / Intensive Care Med 22:519~529
Phua J / 2009 / Has mortality from acute respiratory distress syndrome decreased over time? A systematic review / Am J Respir Crit Care Med 179:220~227
Abel SJ / 1998 / Reduced mortality in association with the acute respiratory distress syndrome (ARDS) / Thorax 53:292~294
Bernard GR / 1994 / The American-European Consensus Conference on ARDS: definitions, mechanisms, relevant outcomes, and clinical trial coordination / Am J Respir Crit Care Med 149(3 Pt 1):818~824
Krafft P / 1996 / The acute respiratory distress syndrome: definitions, severity and clinical outcome. An analysis of 101 clinical investigations / Intensive Care Med 22:519~529
Phua J / 2009 / Has mortality from acute respiratory distress syndrome decreased over time? A systematic review / Am J Respir Crit Care Med 179:220~227
Abel SJ / 1998 / Reduced mortality in association with the acute respiratory distress syndrome (ARDS) / Thorax 53:292~294
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