지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 161 - 166 (6page)
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초록· 키워드
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The deleted in colorectal cancer (DCC) protein mediates attractant responses to netrin during axonogenesis. In the rat trigeminal ganglia (TG), axons must extend toward and grow into the trigeminal nerve to innervate target tissues such as dental pulp. Our present study aimed to investigate the expression of DCC in the TG. Four developmental timepoints were assessed in the experiments: postnatal days 0, 7 and 10and adulthood. RT-PCR and western blotting revealed that the expression of DCC mRNA and protein does not significantly change throughout development. Immunohistochemistry demonstrated that DCC expression in the TG was detectable in the perikarya region of the ganglion cells during development. Nerve injury at 3 and 5 days after the mandibular nerve had been cut did not induce altered expression of DCC mRNA in the TG. Moreover, DCC-positive cell bodies also showed similar immunoreactive patterns after a nerve cut injury. The results of this study suggest that DCC constitutively participates in an axonogenesis attractant in ways other than expression regulation.
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참고문헌 (23)
참고문헌 신청
Anderson RB / 2000 / DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic xenopus / Dev Biol 217 (2) : 244 ~ 253
Chan SS / 1996 / UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues / Cell 87 (2) : 187 ~ 195
Chang C / 2004 / Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase / Science 305 (5680) : 103 ~ 106
De la Torre JR / 1997 / Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC / Neuron 19 (6) : 1211 ~ 1224
Deiner MS / 1997 / Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia / Neuron 19 (3) : 575 ~ 589
Chan SS / 1996 / UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues / Cell 87 (2) : 187 ~ 195
Chang C / 2004 / Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase / Science 305 (5680) : 103 ~ 106
De la Torre JR / 1997 / Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC / Neuron 19 (6) : 1211 ~ 1224
Deiner MS / 1997 / Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia / Neuron 19 (3) : 575 ~ 589
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