지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Gallstones form as the culmination of a complex series of events that results in precipitation of insoluble substances including cholesterol or bilirubin in the gallbladder. Bile formation is essential for lipid digestion and the removal of excess cholesterol from the body either by direct excretion or after conversion to bile acids. Gallstones occur when insoluble lipids and inorganic salts secreted by the liver cannot be solubilized as they normally are in bile by the detergent properties of bile salts. For this to occur, metabolic events must take place to produce bile that contains excess amounts of either cholesterol or bilirubin (supersaturation), both of which are relatively insoluble in aqueous solution. Additionally, physical factors must allow rapid nucleation within the residence time of bile in the biliary tree. (Korean J Med 75:607-615, 2008)
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Acton S / 1996 / Identification of scavenger receptor SR-BI as a high density lipoprotein receptor / Science 271 : 518 ~ 520
Admirand WH / 1968 / The physicochemical basis of cholesterol gallstone formation in man / J Clin Invest 47 : 1043 ~ 1052
Beisiegel U / 1989 / The LDL-receptor-related protein, LRP, is an apolipoprotein Ebinding protein / Nature 341 : 162 ~ 164
Berr F / 1992 / Disorders of bile acid metabolism in cholesterol gallstone disease / J Clin Invest 90 : 859 ~ 868
Bjorkhem I / 1994 / Atherosclerosis and sterol 27-hydroxylase: Evidence for a role of this enzyme in elimination of cholesterol from human macrophages / Proc Natl Acad Sci U
Admirand WH / 1968 / The physicochemical basis of cholesterol gallstone formation in man / J Clin Invest 47 : 1043 ~ 1052
Beisiegel U / 1989 / The LDL-receptor-related protein, LRP, is an apolipoprotein Ebinding protein / Nature 341 : 162 ~ 164
Berr F / 1992 / Disorders of bile acid metabolism in cholesterol gallstone disease / J Clin Invest 90 : 859 ~ 868
Bjorkhem I / 1994 / Atherosclerosis and sterol 27-hydroxylase: Evidence for a role of this enzyme in elimination of cholesterol from human macrophages / Proc Natl Acad Sci U
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