지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Umbilical cord blood (CB) has been an alternative hematopoietic stem cell source especially for patients without an appropriate marrow or mobilized peripheral blood donor. Although many studies have shown similar overall survival rates after CB transplantation compared with other donor sources, higher rate of non-relapse mortality is a major obstacle for a successful CB transplantation. Thus, selecting a best appropriate unit is very important to improve the outcome of CB transplantation. Adequate cell dose and better HLA matching (antigen-level for -A, -B, and allele-level for -DRB1) have been considered most important criteria of donor choice for CB transplantation. In recent, other criteria including non-inherited maternal antigens, HLA-C matching, allele-level matching at 8 loci (-A, -B, -C, -DRB1), and anti-HLA antibodies are also suggested as factors that might affect the outcome of CB transplantation. This review will highlight current issues regarding criteria of donor choice for CB transplantation. Finally, I will introduce the algorithm and detailed guideline for CB selection recently developed in Korea, which may help physicians to choose best unit available.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Ballen KK / 2013 / Umbilical cordblood transplantation: the first 25 years and beyond / Blood 122 : 491 ~ 498
Barker JN / 2010 / Combined effect oftotal nucleated cell dose and HLA match on transplantationoutcome in 1061 cord blood recipients with hematologicmalignancies / Blood 115
Barker JN / 2011 / How I treat: theselection and acquisition of unrelated cord blood grafts / Blood 117 : 2332 ~ 2339
Boo M / 2011 / Cord blood unit access andselection: 2010 and beyond: best practices and emergingtrends in cord blood unit selection / Biol Blood MarrowTransplant 17 (1) : S46
Cutler C / 2011 / Donor-specific anti-HLAantibodies predict outcome in double umbilical cord bloodtransplantation / Blood 118 : 6691 ~ 6697
Barker JN / 2010 / Combined effect oftotal nucleated cell dose and HLA match on transplantationoutcome in 1061 cord blood recipients with hematologicmalignancies / Blood 115
Barker JN / 2011 / How I treat: theselection and acquisition of unrelated cord blood grafts / Blood 117 : 2332 ~ 2339
Boo M / 2011 / Cord blood unit access andselection: 2010 and beyond: best practices and emergingtrends in cord blood unit selection / Biol Blood MarrowTransplant 17 (1) : S46
Cutler C / 2011 / Donor-specific anti-HLAantibodies predict outcome in double umbilical cord bloodtransplantation / Blood 118 : 6691 ~ 6697
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