지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Antibody-mediated rejection (ABMR) in kidney transplant recipients is mediated by donor-specific antibodies. It is the majorcause of graft failure in noncompliant patients and is associated with reduced long-term graft survival. We present a case of delayedrecovery of renal function despite aggressive therapy after acute ABMR. A 49-year-old male on triple-drug maintenanceimmunosuppression (prednisolone, cyclosporine, and azathioprine), who underwent cadaveric donor renal transplantation 14 yearsearlier, visited our clinic with a serum creatinine level (SCr) of 1.9 mg/dL. The kidney biopsy revealed acute ABMR with diffuseC4d immunopositivity. We started steroid pulse therapy and bortezomib with plasmapheresis. Nevertheless, the SCr increased.
Consequently, antithymocyte globulin (ATG) and intravenous immunoglobulin were administered. The SCr increased furtherto 4.1 mg/dL. Therefore, we performed a second kidney biopsy, which showed no change. Finally, we used rituximab. Fortunately,the SCr decreased gradually and returned to baseline.
목차
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참고문헌 (10)
참고문헌 신청
Becker YT / 2004 / Sollinger HW. Rituximab as treatment for refractory kidney transplant rejection / Am J Transplant 4 : 996 ~ 1001
Everly MJ / 2008 / Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection / Transplantation 86 : 1754 ~ 1761
Ginevri F / 2012 / Posttransplant de novo donor-specific hla antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection / Am J Transplant 12
Lamb KE / 2011 / Meier-Kriesche HU. Long-term renal allograft survival in the United States: a critical reappraisal / Am J Transplant 11 : 450 ~ 462
Roberts DM / 2012 / The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review / Transplantation 94 : 775 ~ 783
Everly MJ / 2008 / Bortezomib provides effective therapy for antibody- and cell-mediated acute rejection / Transplantation 86 : 1754 ~ 1761
Ginevri F / 2012 / Posttransplant de novo donor-specific hla antibodies identify pediatric kidney recipients at risk for late antibody-mediated rejection / Am J Transplant 12
Lamb KE / 2011 / Meier-Kriesche HU. Long-term renal allograft survival in the United States: a critical reappraisal / Am J Transplant 11 : 450 ~ 462
Roberts DM / 2012 / The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review / Transplantation 94 : 775 ~ 783
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