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자료유형
학술저널
저자정보
저널정보
대한내과학회 대한내과학회지 대한내과학회지 제86권 제2호
발행연도
2014.1
수록면
142 - 151 (10page)

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Kidney transplantation is the treatment of choice for end stage renal disease. Successful kidney transplantation improves thequality of life and reduces the mortality risk for most patients, when compared with maintenance dialysis. Recent advances,including immunosuppressants, desensitization treatment for highly sensitized kidney transplant candidates, and better medicalcare, have resulted in an increase number of transplants with improved outcomes. However, kidney transplant recipients requireclose follow-up after transplantation since they are on complex immunosuppressive regimens that render them susceptible toinfection, malignancy, and cardiovascular disease. The additional obstacles of kidney transplantation include the lack ofimprovement in long term outcomes, shortage of organs, and multiple co-morbidities due to their underlying chronic kidneydisease. To improve the long-term outcome of renal allograft, physicians must be aware in developing newer immunosuppressiveregimens, with lower side effects, and reduction of death with functioning graft and chronic allograft dysfunction will be thegreatest challenge of all physicians who care for kidney transplant recipients. This review highlights current status of kidneytransplantation in Korea, brief transplant immunology, immunologic tests, donor/recipient evaluation, immunosuppressivemedications, and complications of kidney transplantation involving rejection, post transplantation infections, malignancy,cardiovascular disease and recurrence of primary disease.

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