지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background/Aims: There are controversies surrounding strict control of blood glucose levels in diabetic patients. Therefore, weevaluated the influence of hypoglycemia at admission on the clinical outcomes of patients with acute myocardial infarction (AMI).Methods: We analyzed 5,249 diabetic patients who enrolled in the Korean Acute Myocardial Infarction Registry from November2005 to March 2013. The patients were divided into three groups according to their blood glucose level at admission; Group I:hypoglycemia (≤ 70 mg/dL), Group II: normoglycemia (70-140 mg/dL) and Group III: hyperglycemia (≥ 140 mg/dL). We assessedin-hospital mortality and the major adverse cardiac events based on blood glucose levels at admission.
Results: The mean age was older in group I at 72.6 ± 11.0 years compared to 71.3 ± 10.7 in group II and 70.3 ± 11.1 in group III (p <0.006). A total of 344 patients died during hospitalization. In-hospital mortality was higher in group I at 12.9%, compared to 5.2%in group II and 6.8% in group III (p < 0.006). Multivariable logistic regression analysis determined that the independent predictorsof 1-month mortality were age, Killip class III-IV, cerebrovascular disease, chronic renal failure, acute renal failure, cardiogenicshock, ventricular tachycardia, ejection fraction < 40% and hypoglycemia in admission. The mortality rate at 1 month wassignificantly higher in group I compared to group II (odds ratio [OR] 3.571; 95% confidence interval [CI] 1.465-8.705, p = 0.005)compared to group II and group III (OR 4.088; 95% CI 1.757-9.511, p = 0.001).
Conclusions: Hypoglycemia on admission was an important predictor of in-hospital and one-month mortality in AMI patients withdiabetes mellitus.
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참고문헌 (24)
참고문헌 신청
/ 1998 / Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS
ADVANCE Collaborative Group / 2008 / Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes / N Engl J Med 358 : 2560 ~ 2572
Adler GK / 2009 / Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control / Diabetes 58 : 360 ~ 366
Albers JW / 2010 / Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during t
Cryer PE / 2002 / Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes / Diabetologia 45 : 937 ~ 948
ADVANCE Collaborative Group / 2008 / Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes / N Engl J Med 358 : 2560 ~ 2572
Adler GK / 2009 / Antecedent hypoglycemia impairs autonomic cardiovascular function: implications for rigorous glycemic control / Diabetes 58 : 360 ~ 366
Albers JW / 2010 / Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during t
Cryer PE / 2002 / Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes / Diabetologia 45 : 937 ~ 948
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