지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Colorectal cancer (CRC) affects largely elderly populations. However, older patients with CRC are generally excluded fromrandomized clinical trials, and the healthy subjects who are recruited are not representative of the general elderly patient population.
Nevertheless, recent data from clinical trials specifically targeting elderly patients and related subgroup analyses indicate thatwell-selected elderly patients can have a similar response to that of younger patients. Chronological age should not determine thecandidacy for adjuvant or palliative chemotherapy in elderly patients with CRC. The appropriate management of healthy elderly patientswould mean that they could receive aggressive chemotherapy in a similar regimen to that of younger patients, whereas thecare of frail elderly patients and those with a short life expectancy should focus on palliation. The use of a comprehensive geriatricassessment could allow the use of safe and beneficial chemotherapy regimens in elderly patients with CRC.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Jackson NA / 2009 / Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer: findings from the bolus, infusional, or capecitabine with camptostar-celecoxib study / Cancer 115:2617~2629
Goldberg RM / 2006 / Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/ leucovorin administered bimonthly in elderly patients with colorectal cancer / J Clin Oncol 24:4085~4091
Seymour MT / 2011 / FOCUS2 Investigators; National Cancer Research Institute Colorectal Cancer Clinical Studies Group. Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial / Lancet 377:1749~1759
Cassidy J / 2010 / Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies / J Cancer Res Clin Oncol 136:737~743
Cunningham D / 2013 / AVEX study investigators. Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial / Lancet Oncol 14:1077~1085
Goldberg RM / 2006 / Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/ leucovorin administered bimonthly in elderly patients with colorectal cancer / J Clin Oncol 24:4085~4091
Seymour MT / 2011 / FOCUS2 Investigators; National Cancer Research Institute Colorectal Cancer Clinical Studies Group. Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial / Lancet 377:1749~1759
Cassidy J / 2010 / Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies / J Cancer Res Clin Oncol 136:737~743
Cunningham D / 2013 / AVEX study investigators. Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial / Lancet Oncol 14:1077~1085
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