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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Hypertriglyceridemia a major cause of acute pancreatitis, accounting for up to 10% of all cases. The pathophysiological mechanism of hypertriglyceridemia-induced acute pancreatitis (HTGP) is presumed to involve the hydrolysis of triglycerides by pancreatic lipase resulting in an excess of free fatty acids and elevated chylomicrons, which are thought to increase plasma viscosity and induce ischemia and inflammation in pancreatic tissue. Although the clinical course of HTGP is similar to other forms of acute pancreatitis, the clinical severity and associated complications are significantly higher in patients with HTGP. Therefore, an accurate diagnosis is essential for treatment and prevention of disease recurrence. At present, there are no approved guidelines for the management of HTGP. Different treatment modalities such as apheresis/plasmapheresis, insulin, heparin, fibric acids, and omega-3 fatty acids have been successfully implemented to reduce serum triglycerides. Following acute phase management, lifestyle modifications including dietary adjustments and drug therapy are important for the long-term management of HTGP and the prevention of relapse. Additional studies are required to produce generalized and efficient treatment guidelines for HTGP.
목차
등록된 정보가 없습니다.
참고문헌 (56)
참고문헌 신청
Lankisch PG / 2015 / Acute pancreatitis / Lancet 386:85~96
Xiao AY / 2016 / Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies / Lancet Gastroenterol Hepatol 1:45~55
Zhu Y / 2017 / A study on the etiology, severity, and mortality of 3260 patients with acute pancreatitis according to the revised Atlanta classification in Jiangxi, China over an 8-year period / Pancreas 46:504~509
Fortson MR / 1995 / Clinical assessment of hyperlipidemic pancreatitis / Am J Gastroenterol 90:2134~2139
Koutroumpakis E / 2017 / Management and outcomes of acute pancreatitis patients over the last decade: a US tertiary-center experience / Pancreatology 17:32~40
Xiao AY / 2016 / Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies / Lancet Gastroenterol Hepatol 1:45~55
Zhu Y / 2017 / A study on the etiology, severity, and mortality of 3260 patients with acute pancreatitis according to the revised Atlanta classification in Jiangxi, China over an 8-year period / Pancreas 46:504~509
Fortson MR / 1995 / Clinical assessment of hyperlipidemic pancreatitis / Am J Gastroenterol 90:2134~2139
Koutroumpakis E / 2017 / Management and outcomes of acute pancreatitis patients over the last decade: a US tertiary-center experience / Pancreatology 17:32~40
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