지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
It is well known that the Helicobacter pylori (H. pylori) infection is one of the major causes of gastric cancer development. It can be the remarkable point in cancer prevention strategies, if one-week antibiotic therapy for H. pylori prevents the gastric carcinogenesis. Since the WHO had classified H. pylori as the type I carcinogen for gastric cancer in 1994, academic efforts to investigate whether the treatment of H. pylori infection can prevent gastric carcinogenesis or not have made continuously, however, they have failed to make sufficient evidences despite 15 years of work. In gastric carcinogenesis, a variety of factors is involved. These include specific toxic factors of H. pylori. Subjects with specific genetic polymorphisms associated with gastric carcinogenesis are known to be at high risk for gastric cancer development and dietary environment such as high salt food and nitrogen compound also increase the risk of gastric cancer. H. pylori is involved in the transition from normal mucosa to chronic gastritis. Chronic atrophic gastritis can progress to intestinal metaplasia, dysplasia and finally to adenocarcinoma. And reversibility is lost after the progression to intestinal metaplasia and dysplasia. Therefore, H. pylori eradication dose not simply grantee the prevention of gastric carcinogenesis. We expect that the eradication of H. pylori before the stage of irreversible changes can do preventive effect. And further researches about virulent factors, genetic polymorphism, and other possible environmental conditions related to gastric carcinogenesis are crucial part in establishing preventive strategies for gastric cancer. (Korean J Med 75:503-507, 2008)
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ 2007 / Seroprevalence of Helicobacter pylori in South Korea / Helicobacter 12 : 333 ~ 340
Asaka M / 2001 / Guidelines in the management of Helicobacte
Chang YW / 2002 / Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients / Int J Cancer 101 : 469 ~ 474
Correa P / 1992 / Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention / Ca
Fuccio L / 2007 / Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer / Aliment Pharmacol Ther 25 : 133 ~ 141
Asaka M / 2001 / Guidelines in the management of Helicobacte
Chang YW / 2002 / Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients / Int J Cancer 101 : 469 ~ 474
Correa P / 1992 / Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention / Ca
Fuccio L / 2007 / Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer / Aliment Pharmacol Ther 25 : 133 ~ 141
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