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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제4호
- 발행연도
- 2004.1
- 수록면
- 244 - 248 (5page)
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초록· 키워드
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Background : The overexpression of epidermal growth factor receptor (EGFR) and c-erbB-
2 oncogenes has been implicated in the development of many types of cancer. However, the
role of EGFR and c-erbB-2 overexpression in hepatocellular carcinoma (HCC) has not been
fully elucidated. Methods : The aim of this study was to evaluate the immunohistochemical
expression of EGFR and c-erbB-2 oncoprotein in a series of 52 HCCs. Results : All but one
of the HCC tumor tissues were negative for EGFR monoclonal antibody, clone H11. All of the
HCC tumor tissue samples were negative for EGFR monoclonal antibody, clone 29.1.1. However,
strong EGFR immunoreactivity was detected in sinusoidal endothelial cells of HCC in
25 tumors (48%) using EGFR 29.1.1 antibody. The expression of c-erbB-2 was observed in
6% (3/52) of the HCCs. No significant correlation was found between p53 mutation and the
expression of c-erbB-2. Conclusion : Our results suggest that both EGFR and c-erbB-2 oncoprotein
overexpressions in tumor cells are rare and do not seem to predominantly contribute
to the malignant phenotype in HCC.
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참고문헌 (24)
참고문헌 신청
/ / Expression of HER-2/neuoncoprotein and epidermal growth factor receptor and prognosisin gastric carcinoma : 235 ~ 9
/ / Oncogenicexpression in cholangiocarcinoma and in normal hepatic development : 1163 ~ 8
/ / Type 1 (EGFR-related) family of growth fac-tor receptors and their ligands. : 1 ~ 1 24
/ / c-erbB-2 in HCC 247 : 281 ~ 302
/ 1988 / Epidermalgrowth factor receptor in meningiomas is expressed predominantlyon endothelial cells : 2139 ~ 2144
/ / Oncogenicexpression in cholangiocarcinoma and in normal hepatic development : 1163 ~ 8
/ / Type 1 (EGFR-related) family of growth fac-tor receptors and their ligands. : 1 ~ 1 24
/ / c-erbB-2 in HCC 247 : 281 ~ 302
/ 1988 / Epidermalgrowth factor receptor in meningiomas is expressed predominantlyon endothelial cells : 2139 ~ 2144
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