지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Kinship testing in forensic casework is largely based on a likelihood ratio (LR)approach with short tandem repeat (STR) markers; however, in order to efficiently identify potential relatives in a specific population, the threshold values for kinship prediction should be determined by analyzing the kinship index distributions of the population in question. In this study, 250,000 DNA profiles were simulated using allele frequencies at 20 autosomal STR loci in Koreans, then the LRs were calculated for true close relatives and unrelated pairs. The LR distributions in related and unrelated pairs under a given relationship were compared in 2 sets of 13 Combined DNA Index System (CODIS) and 20 STR profiles. Using 13 CODIS STRs, true relatives in parent/child and full-sibling relationships were sufficiently discriminated from unrelated pairs with LR thresholds of 1,000 and 100, respectively. However, the CODIS STRs lacked the discriminatory power to differentiate between related and unrelated pairs in uncle/nephew and first cousin relationships due to high false-positive and false-negative rates with a LR threshold of 10. Increasing the number of STR loci to 20 increased discrimination of close relatives, but high false results remained in uncle/nephew and first cousin relationships. The kinship index data from this study will help make decisions on various kinship testing and familial searching in Koreans
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bieber FR / 2006 / Human genetics. Finding criminals through DNA of their relatives / Science 312 : 1315 ~ 1316
Budowle B / 2001 / CODIS STR loci data from 41 sample populations / J Forensic Sci 46 : 453 ~ 489
Butler JM / 1998 / Forensic applications of mitochondrial DNA / Trends Biotechnol 16 : 158 ~ 162
Butler JM / 2009 / Fundamentals of forensic DNA typing / Elsevier Academic Press : 489 ~ 494
Butler JM / 2012 / Biology and genetics of new autosomal STR loci useful for forensic DNA analysis / Forensic Sci Rev 24 : 15 ~ 26
Budowle B / 2001 / CODIS STR loci data from 41 sample populations / J Forensic Sci 46 : 453 ~ 489
Butler JM / 1998 / Forensic applications of mitochondrial DNA / Trends Biotechnol 16 : 158 ~ 162
Butler JM / 2009 / Fundamentals of forensic DNA typing / Elsevier Academic Press : 489 ~ 494
Butler JM / 2012 / Biology and genetics of new autosomal STR loci useful for forensic DNA analysis / Forensic Sci Rev 24 : 15 ~ 26
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