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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제4호
- 발행연도
- 2007.1
- 수록면
- 244 - 251 (8page)
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Background : Nonsteroidal anti-inflammatory drug activated gene (NAG-1) has proapoptotic
activities in the colon and also in gastric cancer cells that lack any endogenous COX-2 expression.
Recent studies have suggested that the proa- poptotic activity of NAG-1 is cell type specific.
I investigated the cell proliferation, invasiveness and apoptosis in Hep3B cells and SNU719
cells by determining the different expression levels of NAG-1. In addition, I examined the gene
profile in the Hep3B cells that have a stable expression of NAG-1. Methods : SNU719 cells
and several clones of Hep3B cells with a stable expression of NAG-1 were used. I reduced the
expression level of NAG-1 via the RNAi method. An Agilent Human 22k microarray was used
for studying the gene profile in Hep3B cells that had a stable expression of NAG-1. Results :
The expression level of NAG-1 did not influence apoptosis, cell proliferation and invasiveness
in Hep3B cells. There was no correlation between the reduction of the endogenous NAG-1
expression and cell proliferation, including invasiveness, in the SNU719 cells. However, a
knocked-down NAG-1 expression protected against apoptosis in the SNU719 cells. The microarray
analysis results showed that 0.25% (58/22,575) of the genes were induced or repressed
more than three fold in the Hep3B cells that had a stable expression of NAG-1. Conclusions
: Proapoptotic activity of NAG-1 is found in gastric cancer cells, but not in hepatocellular
cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1996 / Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway 52 : 237
/ 1996 / Enhancement by neurotensin of hepatocarcinogenesis by N-nitrosomorpholine in Sprague-Dawley rats 110 : 57 ~ 61
/ 1998 / New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma 27 : 943 ~ 950
/ 2000 / Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic
/ 2001 / Cyclooxygenase inhibitors regulate the expression of a TGF- superfamily member that has proapoptotic and antitumorigenic activities 59 : 901 ~ 908
/ 1996 / Enhancement by neurotensin of hepatocarcinogenesis by N-nitrosomorpholine in Sprague-Dawley rats 110 : 57 ~ 61
/ 1998 / New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma 27 : 943 ~ 950
/ 2000 / Methylation and downregulated expression of mac25/insulin-like growth factor binding protein-7 is associated with liver tumorigenesis in SV40T/t antigen transgenic
/ 2001 / Cyclooxygenase inhibitors regulate the expression of a TGF- superfamily member that has proapoptotic and antitumorigenic activities 59 : 901 ~ 908
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