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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제39권 제5호
- 발행연도
- 2005.1
- 수록면
- 313 - 319 (7page)
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초록· 키워드
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Background : Although the genetic determinants of most sporadic breast cancers remain unknown, the understanding of the molecular and genetic events that contribute to breast carcinogenesis has been significantly advanced. We investigated the clinicopathologic significance of allelic imbalance or mutation of both p53 and PTEN tumor suppressor genes in sporadic breast carcinomas. Methods : Genomic DNA from 62 breast carcinoma cases was extracted from paraffin blocks, and PCR was performed to determine loss of heterozygosity (LOH) for DNA markers around the p53 and PTEN genes and to amplify exons 5, 6, 7, and 8 of p53 and all 9 coding axons of PTEN. Results : Somatic p53 mutations were detected in 6 (9.7%) of the 62 cases. LOH for DNA markers surrounding p53 was observed in 18 (29.0%) of the 62 cases. LOH for DNA markers surrounding PTEN was detected in 29 (46.8%) of the 62 cases. Only one case (1.6%) showed somatic PTEN mutations. Tumors with LOH on 17p or p53 mutation were large in size and negative for ER, had a high Ki-67 index, and exhibited p53 immunoreactivity (p<0.05). Tumors with LOH on 10q23 were associated with c-erbB-2 positivity (p=0.018). Conclusions : Our results indicate that LOH at 17p and/or p53 mutation is significantly associated with the aggressive pathologic parameters of breast cancer.
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참고문헌 (29)
참고문헌 신청
/ / Allelotyping of ductal carcinomain situ of the breast deletion of loci on 8p 55 : 3399 ~ 405
/ / Identification of a candidatetumor suppressor gene 3 that ismutated in multiple advanced cancers 15 : 356 ~ 62
/ 1985 / Hereditary cancer,oncogenes and antioncogenes 45 : 1437 ~ 43
/ 1992 / Inherited p53 gene mutationsin breast cancer 52 : 2984 ~ 6
/ 1994 / Loss of heterozygosity in familial tumorsfrom three BRCA 1-linked kindreds 54 : 6069 ~ 72
/ / Identification of a candidatetumor suppressor gene 3 that ismutated in multiple advanced cancers 15 : 356 ~ 62
/ 1985 / Hereditary cancer,oncogenes and antioncogenes 45 : 1437 ~ 43
/ 1992 / Inherited p53 gene mutationsin breast cancer 52 : 2984 ~ 6
/ 1994 / Loss of heterozygosity in familial tumorsfrom three BRCA 1-linked kindreds 54 : 6069 ~ 72
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현미부수체 표지자를 이용한 연령에 따른 유방암 환자의 분자생물학적 차이에 관한 연구
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269. 간세포암 조직에서 염색체 10q23 부위 LOH(loss of heterozygosity)의 발현양상
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Prediction and Analysis of Breast Cancer Related Deleterious Non-Synonymous Single Nucleotide Polymorphisms in the PTEN Gene
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