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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제2호
- 발행연도
- 2011.1
- 수록면
- 125 - 131 (7page)
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초록· 키워드
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Background: Micropapillary carcinoma (MPC) is known to have a worse prognosis than the other subtypes of breast cancer. Occasionally, MPC is observed in association with invasive ductal carcinoma not otherwise specified (IDC NOS), as well as mucinous carcinoma. Methods: We examined the immunohistochemical expression of an estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) in 127 cases of surgically resected MPC or IDC NOS with MPC. Further, we classified these cases based on their immunohistochemical profile. Results: Among the IDC NOS with MPC cases, 47 were luminal A (62.7%), 10 were luminal B (13.3%), and 9 were HER2 (12.0%). The MPC cases included 4 luminal A (50.0%), 2 luminal B (25.0%) and 1 HER2 (12.5%) subtypes. Of the mucinous carcinomas with MPC, 4 were grouped as luminal A (57.1%), 1 as luminal B (14.3%), and 2 as HER2 (28.6%) subtypes. However, among the mucinous carcinomas, 33 were categorized as luminal A (89.2%), 3 as luminal B (8.1%), and 1 as HER2 (2.7%) subtype, indicating a low incidence of HER2 subtype as compared to the other subtypes. Conclusions: The luminal B and HER2 subtypes were prevalent in carcinomas with MPC. This result explains the poor prognosis of breast carcinomas with an MPC pattern.
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참고문헌 (23)
참고문헌 신청
Bal A / 2008 / Prognostic significance of micropapillary pattern in pure mucinous carcinoma of the breast / Int J Surg Pathol 16 : 251 ~ 256
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295 : 2492 ~ 2502
Chen L / 2008 / Breast carcinoma with micropapillary features: clinicopathologic study and long-term follow-up of 100 cases / Int J Surg Pathol 16 : 155 ~ 163
De la Cruz C / 2004 / Invasive micropapillary carcinoma of the breast: clinicopathological and immunohistochemical study / Pathol Int 54 : 90 ~ 96
Kamat AM / 2006 / The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma / J Urol 175 (3 Pt 1) : 881 ~ 885
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295 : 2492 ~ 2502
Chen L / 2008 / Breast carcinoma with micropapillary features: clinicopathologic study and long-term follow-up of 100 cases / Int J Surg Pathol 16 : 155 ~ 163
De la Cruz C / 2004 / Invasive micropapillary carcinoma of the breast: clinicopathological and immunohistochemical study / Pathol Int 54 : 90 ~ 96
Kamat AM / 2006 / The case for early cystectomy in the treatment of nonmuscle invasive micropapillary bladder carcinoma / J Urol 175 (3 Pt 1) : 881 ~ 885
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