지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제3호
- 발행연도
- 2012.1
- 수록면
- 246 - 252 (7page)
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Background: This study was conducted to clarify the frequency of the BRAF mutation in primary melanomas and its correlation with clinicopathologic parameters. Methods: We analyzed the frequency of BRAF mutation in patients with primary cutaneous melanoma (n=58) or non-cutaneous one (n=27) by performing dual priming oligonucleotide-based multiplex real-time polymerase chain reaction to isolate and to purify the DNA from the formalin-fixed and paraffin-embedded tumors. Results: The BRAF mutation was found in 17.2% (10/58) of patients with primary cutaneous melanoma and 11.1% (3/27) of those with non-cutaneous melanoma. The frequency of BRAF mutation was not correlated with any clinicopathologic parameters with the exception of the patient age. The frequency of the BRAF mutation was significantly higher in patients younger than 60 years as compared with those older than 60 years (p=0.005). Conclusions: Compared with previous reports, our results showed that the frequency of the BRAF mutation was relatively lower in patients with primary cutaneous melanoma. Besides, our results also showed that the frequency of the BRAF mutation had an inverse correlation with the age. Further studies are warranted to exclude methodological bias, to elucidate the difference in the frequency of the BRAF mutation from the previous reports from a Caucasian population and to provide an improved understanding of the molecular pathogenesis of malignant melanoma.
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참고문헌 (25)
참고문헌 신청
Akslen LA / 2005 / BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival / J Invest Dermatol 125
Balch CM / 2009 / Final version of 2009 AJCC melanoma staging and classification / J Clin Oncol 27 : 6199 ~ 6206
Bastian BC / 2000 / Gene amplifications characterize a
Bauer J / 2011 / BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the pri
Chabner BA / 1993 / Biological basis for cancer treatment / Ann Intern Med 118 : 633 ~ 637
Balch CM / 2009 / Final version of 2009 AJCC melanoma staging and classification / J Clin Oncol 27 : 6199 ~ 6206
Bastian BC / 2000 / Gene amplifications characterize a
Bauer J / 2011 / BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the pri
Chabner BA / 1993 / Biological basis for cancer treatment / Ann Intern Med 118 : 633 ~ 637
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