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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제2호
- 발행연도
- 2007.1
- 수록면
- 95 - 102 (8page)
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Background : The catalytic subunit of telomerase, hTERT (telomerase reverse transcriptase),
is one of the most important components of telomerase, and performs a pivotal role in the mechanism
underlying the regulation of telomerase activity in cellular immortalization and carcinogenesis.
The principal objective of this study was to investigate hTERT expression in patients
with non-small cell lung carcinomas (NSCLCs), and to evaluate its clinical significance and
association with the expression of p16 and p53. Methods : Using tissue microarray, the protein
expression profiles of hTERT, p16 and p53 were investigated via immunohistochemistry
in 167 samples of NSCLCs. Results : Expression was observed in 54.5% (91/167) of the
tumors, which were predominantly squamous cell carcinomas. Patients evidencing hTERT
expression in their tumors exhibited significantly poorer survival rates than did patients without
hTERT expression in early-stage NSCLCs (p=0.0125). According to the results of our Cox
regression analysis, hTERT expression proved to be an independent prognostic factor (p=
0.006), particularly for squamous cell carcinomas (p=0.019). hTERT expression was not correlated
with p16 expression, but was rather associated with the expression of p53 (p=0.002).
Conclusions : Our results show that hTERT may perform a function in the progression of
NSCLC, and that its detection may be useful in predicting the prognosis of NSCLC patients
in the early stages of the disease, as well as in the development of a targeted therapy in these
tumors.
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