지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제6호
- 발행연도
- 2011.1
- 수록면
- 589 - 595 (7page)
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초록· 키워드
오류제보하기
Background: CD44 protein is known as a homing cellular adhesion molecule that is linked to di-verse cellular functions such as adhesion, migration and invasion, which are all important in can-cer progression and metastasis. The expression of CD44 standard and variant isoforms (CD44 standard isoform [CD44s] and CD44 splice variants containing exon v6 [CD44v6], respectively) is associated with an unfavorable clinical outcome in various neoplasms. Methods: Forty patients who were diagnosed with diffuse large B-cell lymphoma (DLBCL) through biopsy at Hanyang University Hospital between 1996 and 2003 were included in this study. CD44 proteins expres¬sion was analyzed by immunohistochemical staining on a tissue microarray and the correlation of CD44 with the types of DLBCL and clinical parameters, including the factors defined by the Inter-national Prognostic Index, was evaluated. Results: A high CD44s and intermediate to strong CD44v6 expression, including cytoplasmic membranous staining patterns, was present in 35% (14/40) and 25% (10/40) of DLBCL patients, respectively. High CD44s expression was correlated significantly with non-germinal center B-cell-like types (non-GCB, p=0.004) and patients with old age (p=0.041). Conclusions: High CD44s expression may be significantly associated with the non-GCB type compared to the GCB type and may be essential to the prediction of disease out¬come in tumor stage III in DLBCL patients.
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참고문헌 (24)
참고문헌 신청
/ 1993 / A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project / N Engl J Med 329 : 987 ~ 994
/ 1997 / A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s Lymphoma Classification Project / Blood
Afify A / 2008 / Expression of CD44s, CD44v6, and hyaluronan across the spectrum of normal-hyperplasia-carcinoma in breast / Appl Immunohistochem Mol Morphol 16 : 121 ~ 127
Alizadeh AA / 2000 / Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling / Nature 403 : 503 ~ 511
Aruffo A / 1990 / CD44 is the principal cell surface receptor for hyaluronate / Cell 61 : 1303 ~ 1313
/ 1997 / A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s Lymphoma Classification Project / Blood
Afify A / 2008 / Expression of CD44s, CD44v6, and hyaluronan across the spectrum of normal-hyperplasia-carcinoma in breast / Appl Immunohistochem Mol Morphol 16 : 121 ~ 127
Alizadeh AA / 2000 / Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling / Nature 403 : 503 ~ 511
Aruffo A / 1990 / CD44 is the principal cell surface receptor for hyaluronate / Cell 61 : 1303 ~ 1313
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