지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제2호
- 발행연도
- 2017.1
- 수록면
- 159 - 164 (6page)
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We describe an ovarian mucinous neoplasm that histologically resembles lobular endocervical glandular hyperplasia (LEGH) containing pyloric gland type mucin in a patient with Peutz-Jeghers syndrome (PJS). Although ovarian mucinous tumors rarely occur in PJS patients, their pyloric gland phenotype has not been clearly determined. The histopathologic features of the ovarian mucinous tumor were reminiscent of LEGH. The cytoplasmic mucin was stained with periodic acid-Schiff reaction after diastase treatment but was negative for Alcian blue pH 2.5, suggesting the presence of neutral mucin. Immunohistochemically, the epithelium expressed various gastric markers, including MUC6, HIK1083, and carbonic anhydrase-IX. Multiple ligation-dependent probe amplification detected a germline heterozygous deletion mutation at exons 1–7 of the STK11 gene (c.1-?_920+?del) in peripheral blood leukocytes and mosaic loss of heterozygosity in ovarian tumor tissue. Considering that LEGH and/or gastric-type cervical adenocarcinoma can be found in patients with PJS carrying germline and/or somatic STK11 mutations, our case indicates that STK11 mutations have an important role in the proliferation of pyloric-phenotype mucinous epithelium at various anatomical locations.
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등록된 정보가 없습니다.
참고문헌 (5)
참고문헌 신청
Ferry JA / 1994 / Oxyphilic Sertoli cell tumor of the ovary: a report of three cases, two in patients with the Peutz-Jeghers syndrome / Int J Gynecol Pathol 13 : 259 ~ 266
Jenne DE / 1998 / Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase / Nat Genet 18 : 38 ~ 43
Kato N / 2011 / Pyloric gland metaplasia/differentiation in multiple organ systems in a patient with Peutz-Jegher’s syndrome / Pathol Int 61 : 369 ~ 372
Kondo T / 2005 / Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical an
Kuragaki C / 2003 / Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix / Lab Invest 83 : 35 ~ 45
Jenne DE / 1998 / Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase / Nat Genet 18 : 38 ~ 43
Kato N / 2011 / Pyloric gland metaplasia/differentiation in multiple organ systems in a patient with Peutz-Jegher’s syndrome / Pathol Int 61 : 369 ~ 372
Kondo T / 2005 / Endocervical adenocarcinomas associated with lobular endocervical glandular hyperplasia: a report of four cases with histochemical and immunohistochemical an
Kuragaki C / 2003 / Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix / Lab Invest 83 : 35 ~ 45
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