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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제5호
- 발행연도
- 2018.1
- 수록면
- 323 - 330 (8page)
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초록· 키워드
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Background: Intratumoral fibrosis (ITF) is a frequent histologic finding in solid organ tumors. Renal cell carcinoma (RCC) is a highly vascularized tumor with different shapes and degrees of ITF and inflammation. ITF is a poor prognostic factor, especially in breast cancer, and is related to intratumoral necrosis (ITN) and intratumoral inflammation (ITI). However, the significance of ITF in RCC has not been fully studied. In this study, we evaluate the relationships between ITF and other clinicopathologic parameters associated with RCC prognosis. Methods: ITF was evaluated in 204 clear cell renal cell carcinoma (CCRCC) specimens according to presence and grade of fibrosis, degree of ITI, and presence of ITN. Lysyl oxidase (LOX) expression in tumor cells was also evaluated with clinicopathologic parameters. Results: Among 204 CCRCC cases, 167 (81.7%) showed ITF, 71 (34.8%) showed ITI, 35 (17.2%) showed ITN, and 111 (54.4%) showed LOX expression. ITF correlated with Fuhrman nuclear grade (p = .046), lymphovascular invasion (LVI) (p = .027), and ITN (p = .036). Patients with ITF had a poor five-year overall survival rate (p = .104). Conclusions: ITF is related to other poor prognostic factors in CCRCC, such as Fuhrman nuclear grade, ITN, and LVI, but ITF itself had no significant correlation with prognosis of CCRCC.
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참고문헌 (33)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66:7~30
정재영 / 2017 / Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea / Cancer Research and Treatment 49(3):607~615
Srigley JR / 2013 / The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia / Am J Surg Pathol 37:1469~1489
Gerlinger M / 2012 / Intratumor heterogeneity and branched evolution revealed by multiregion sequencing / N Engl J Med 366:883~892
Beksac AT / 2017 / Heterogeneity in renal cell carcinoma / Urol Oncol 35:507~515
정재영 / 2017 / Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea / Cancer Research and Treatment 49(3):607~615
Srigley JR / 2013 / The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia / Am J Surg Pathol 37:1469~1489
Gerlinger M / 2012 / Intratumor heterogeneity and branched evolution revealed by multiregion sequencing / N Engl J Med 366:883~892
Beksac AT / 2017 / Heterogeneity in renal cell carcinoma / Urol Oncol 35:507~515
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