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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제42권 제4호
- 발행연도
- 2008.1
- 수록면
- 208 - 214 (7page)
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Background : Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the human liver. However, the molecular changes and mechanisms that regulate the development and progression of HCC remain unclear. Beta-catenin is known as a multi-functional protein that acts as a regulator of the cadherin-mediated cell-cell adhesion system and also in
the Wingless/Wnt signal transduction pathway. The aim of this study was to investigate the expression of β-catenin and its possible role in HCC. Methods : We investigated the expression of β-catenin, Ki-67, TP53, α-smooth muscle actin and CD34 by performing immunohistochemical staining for 61 specimens of HCC and their adjacent non-tumorous tissue. We also examined the relationship between the nuclear expression of β-catenin and the clinicopathologic parameters. Results : The altered expression of β-catenin was not detected in the nontumorous liver tissue. The nuclear expression of β-catenin was observed in approximately 16%(10/61) of the HCC specimens. Double immunohistochemical staining for β-catenin and E-cadherin showed a close relationship between nuclear translocation of β-catenin and the loss of
the membranous E-cadherin expression. Significant correlation was found between the nuclear translocation of β-catenin and the tumor size, tumor necrosis and the presence of microvessel invasion and intrahepatic metastasis (p<0.05). Conclusions : This data indicates that nuclear
translocation of β-catenin could play a role in the growth and progression of HCC.
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참고문헌 (23)
참고문헌 신청
Asayama Y / 2002 / The mode of tumour progression in combined hepatocellular carcinoma and cholangiocarcinoma: an immunohistochemical analysis of E-cadherin, alpha-cate
Behrens J / 1999 / Cadherins and catenins: role in signal transduction and tumor progression / Cancer Metastasis Rev 18 : 15 ~ 30
Crawford HC / 1999 / The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors / Oncogene 18 : 2883 ~ 2891
Cui J / 2001 / Mutation and overexpression of the beta-catenin gene may play an important role in primary hepatocellular carcinoma among Chinese people / J Cancer Res Clin O
Haydon RC / 2002 / Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma / Int J Cancer 102 : 338 ~ 342
Behrens J / 1999 / Cadherins and catenins: role in signal transduction and tumor progression / Cancer Metastasis Rev 18 : 15 ~ 30
Crawford HC / 1999 / The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors / Oncogene 18 : 2883 ~ 2891
Cui J / 2001 / Mutation and overexpression of the beta-catenin gene may play an important role in primary hepatocellular carcinoma among Chinese people / J Cancer Res Clin O
Haydon RC / 2002 / Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma / Int J Cancer 102 : 338 ~ 342
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