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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제2호
- 발행연도
- 2015.1
- 수록면
- 118 - 128 (11page)
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Background: Although there are controversies regarding the benefit of fluoropyrimidine-based adjuvant chemotherapy in patients with microsatellite instability–high (MSI-H) colorectal cancer (CRC), the pathologic features affecting postchemotherapeutic prognosis in these patients have not been fully identified yet. Methods: A total of 26 histopathologic and immunohistochemical factors were comprehensively evaluated in 125 stage II or III MSI-H CRC patients who underwent curative resection followed by fluoropyrimidine-based adjuvant chemotherapy. We statistically analyzed the associations of these factors with disease-free survival (DFS). Results: Using a Kaplan-Meier analysis with log-rank test, we determined that ulceroinfiltrative gross type (p=.003), pT4 (p<.001), pN2 (p=.002), perineural invasion (p=.001), absence of peritumoral lymphoid reaction (p=.041), signet ring cell component (p=.006), and cribriform comedo component (p=.004) were significantly associated with worse DFS in patients receiving oxaliplatin-based adjuvant chemotherapy (n=45). By contrast, pT4 (p<.001) and tumor budding-positivity (p=.032) were significant predictors of poor survival in patients receiving non-oxaliplatin–based adjuvant chemotherapy (n=80). In Cox proportional hazards regression model-based univariate and multivariate analyses, pT category (pT1-3 vs pT4) was the only significant prognostic factor in patients receiving non-oxaliplatin–based adjuvant chemotherapy, whereas pT category, signet ring cell histology and cribriform comedo histology remained independent prognostic factors in patients receiving oxaliplatin-based adjuvant chemotherapy. Conclusions: pT4 status is the most significant pathologic determinant of poor outcome after fluoropyrimidine-based adjuvant chemotherapy in patients with stage II/III MSI-H CRC.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물
Arnold CN / 2003 / Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines / Int J Cancer 106 : 66 ~ 73
Bettington M / 2013 / The serrated pathway to colorectal carcinoma: current concepts and challenges / Histopathology 62 : 367 ~ 386
Bosman FT / 2010 / WHO classification of tumours of the digestive system / IARC Press
Carethers JM / 1999 / Mismatch repair proficiency and in vitro response to 5-fluorouracil / Gastroenterology 117 : 123 ~ 131
Arnold CN / 2003 / Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines / Int J Cancer 106 : 66 ~ 73
Bettington M / 2013 / The serrated pathway to colorectal carcinoma: current concepts and challenges / Histopathology 62 : 367 ~ 386
Bosman FT / 2010 / WHO classification of tumours of the digestive system / IARC Press
Carethers JM / 1999 / Mismatch repair proficiency and in vitro response to 5-fluorouracil / Gastroenterology 117 : 123 ~ 131
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