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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제2호
- 발행연도
- 2015.1
- 수록면
- 105 - 111 (7page)
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초록· 키워드
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Background: C-reactive protein (CRP) is an acute phase reactant synthesized in the liver. CRP immunoreactivity is a feature of inflammatory hepatocellular adenomas with a higher risk of malignant transformation. A high serum CRP level denotes poor prognosis in hepatocellular carcinoma (HCC) patients. This study was conducted to determine whether CRP is produced in HCC and to assess the clinicopathologic significance of CRP expression in cancer cells. Methods: CRP immunoreactivity was examined in treatment-naïve HCCs (n=224) using tissue microarrays and was correlated with clinicopathologic parameters. The expression of CRP mRNA and protein was also assessed in 12 HCC cases by quantitative real-time polymerase chain reaction and immunoblotting. Hep3B and SNU-449 HCC cell lines were used for the analysis of CRP mRNA regulation by interleukin 6 (IL-6). Results: CRP was expressed in 133 of 224 HCCs (59.4%) with a variable degree of immunoreactivity (grade 1 in 25.9%; grade 2 in 20.1%; grade 3 in 13.4%). There was an inverse relationship between grade 3 CRP immunoreactivity and cancer-specific survival (p=.0047), while no associations were found with other parameters, including recurrence-free survival. The CRP mRNA expression level was significantly higher in CRP immunopositive cases than in immunonegative cases (p<.05). CRP mRNA expression was increased in Hep3B cells, but was not detected in SNU-449 cells even after IL-6 treatment. Conclusions: We report the expressionof CRP in HCC for the first time. CRP expression was associated with poor cancer-specific survival in patients with resectable HCC.
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참고문헌 (23)
참고문헌 신청
Bioulac-Sage P / 2007 / Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry / Hepatology 46 : 740 ~ 748
Bioulac-Sage P / 2010 / Hepatic resection for inflammatory hepatocellular adenomas : pathological identification of micronodules expressing inflammatory proteins / Liver Int
Castano-Rodriguez N / 2014 / Pattern-recognition receptors and gastric cancer / Front Immunol 5 : 336 ~
Castell JV / 1989 / Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes / FEBS Lett 242 : 237 ~ 239
Castell JV / 1990 / Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6 / Hepatology 12 : 1179 ~ 1186
Bioulac-Sage P / 2010 / Hepatic resection for inflammatory hepatocellular adenomas : pathological identification of micronodules expressing inflammatory proteins / Liver Int
Castano-Rodriguez N / 2014 / Pattern-recognition receptors and gastric cancer / Front Immunol 5 : 336 ~
Castell JV / 1989 / Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes / FEBS Lett 242 : 237 ~ 239
Castell JV / 1990 / Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6 / Hepatology 12 : 1179 ~ 1186
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