지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Sudden unexplained nocturnal death syndrome (SUNDS) occurs predominantly in Southeast Asian people including Koreans. SUNDS is problematic for forensic pathologists because the diagnosis depends on the “exclusion of diagnosis.” Moreover, the pathogenesis of SUNDS is still unclear although some cases are known to be intimately related to the Brugada syndrome. Connexin 43 (Cx43) is a principal protein of gap junction in adult cardiac myocytes, being distributed to the intercalated discs and phosphorylated in normal condition. Ischemia and hypoxia alter the expression of total Cx43 (tCx43) resulting in redistribution of non-phosphorylated Cx43 (npCx43) to the sarcoplasm or lateral cell borders of cardiac myocytes by continuing dephosphorylation. This study aimed to compare the immunoexpression pattern of Cx43 in the cardiac myocytes of SUNDS and ischemic heart disease (IHD). The study group was 26 cases of SUNDS and the control group of 24 cases of IHD with severe coronary atherosclerosis, showing no myocardial ischemic change. There was a significantly different expression of both tCx43 and npCX43 between the SUNDS and IHD group. A greater reduction in both tCx43 and npCx43 and a more delayed redistribution pattern was seen in the myocardium of SUNDS when compared with IHD. In conclusion, these results suggest that the reduced Cx43 expression in SUNDS may be inherent and indicate a risk of arrhythmia.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Cheng J / 2011 / Sudden unexplained nocturnal death syndrome in Southern China: an epidemiological survey and SCN5A gene screening / Am J Forensic Med Pathol 32:359~363
Vatta M / 2002 / Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome / Hum Mol Genet 11:337~345
Liu C / 2014 / Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder? / Forensic Sci Int 236:38~45
Schulz R / 2015 / Connexin 43 is an emerging therapeut ic target in i schemia/ reper fus ion injury, cardioprotection and neuroprotection / Pharmacol Ther 153:90~106
Lampe PD / 2004 / The effects of connexin phosphorylation on gap junctional communication / Int J Biochem Cell Biol 36:1171~1186
Vatta M / 2002 / Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome / Hum Mol Genet 11:337~345
Liu C / 2014 / Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder? / Forensic Sci Int 236:38~45
Schulz R / 2015 / Connexin 43 is an emerging therapeut ic target in i schemia/ reper fus ion injury, cardioprotection and neuroprotection / Pharmacol Ther 153:90~106
Lampe PD / 2004 / The effects of connexin phosphorylation on gap junctional communication / Int J Biochem Cell Biol 36:1171~1186
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