지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제3호
- 발행연도
- 2004.1
- 수록면
- 133 - 137 (5page)
이용수
초록· 키워드
오류제보하기
Background : The most consistent chromosomal abnormality in ependymomas, is loss of
22q (17-75%) and gain of 1q (0-50%). However, significance of this abnormality is uncertain.
Methods : Genomic imbalances in 27 Korean ependymomas, including 21 low grade
ependymomas, 4 anaplastic and 2 myxopapillary ependymomas, were analyzed by degenerate
oligonucleotide primed-PCR-comparative genomic hybridization. Results : Common
gains were found in 17 (63%), 20q (59%), 9q34 (41%), 15q24-qter (33%), 11q13 (30%),
12q23 (26%), 7q23-qter (26%), 16q23-qter (30%), 19 (26%), and 1q32-qter (22%). DNA
amplification was identified in 12 tumors (44%). Chromosomal loss was a less common
occurrence in our study, but was found in 13q (26%), 6q (19%), and 3 (11%). Conclusion :
The recurrent gains or losses of the chromosomal regions which were identified in this study
provide candidate regions that may be involved in the development and progression of
ependymomas.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bijlsma E.K / 1995 / Molecular analysis of genetic changes in ependymomas. / Genes Chromosomes Cancer 13 : 272 ~ 277
Carter M / 2002 / Genetic abnormalities detected in ependymomas by comparative genomic hybridisation. / Br J Cancer 86 : 929 ~ 939
Dal Cin P / 1988 / Cytogenetic findings in a supratentorial ependymoma. / Cancer Genet Cytogenet 30 : 289 ~ 293
Giovane A / 1995 / Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes. / Genomics 2
Granzow M / 2001 / Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics. / Cancer Genet Cytogenet 130 :
Carter M / 2002 / Genetic abnormalities detected in ependymomas by comparative genomic hybridisation. / Br J Cancer 86 : 929 ~ 939
Dal Cin P / 1988 / Cytogenetic findings in a supratentorial ependymoma. / Cancer Genet Cytogenet 30 : 289 ~ 293
Giovane A / 1995 / Locations of the ets subfamily members net, elk1, and sap1 (ELK3, ELK1, and ELK4) on three homologous regions of the mouse and human genomes. / Genomics 2
Granzow M / 2001 / Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics. / Cancer Genet Cytogenet 130 :
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