지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제2권 제1호
- 발행연도
- 2014.1
- 수록면
- 8 - 15 (8page)
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초록· 키워드
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For allergists, itch is the most important symptom of atopic dermatitis (AD), and at the same time, the most difficult-to-manage complaint of atopic patient. Rather than just one symptom of AD, itch has more profound clinical significance in the following sense: itch, as a key component of so-called ‘itch-scratch’ vicious-cycle, plays a central role in the development and persistence of AD, thus, treating itch is not just alleviating one symptom of AD, but stopping genesis and progress of AD. In other words, itch is AD in itself. Pathomechanism underlying development of itch in AD could be summarized as follows: First, exogenous triggering factors penetrate impaired barrier, leading to allergic skin inflammation. Resulting characteristic itch of AD is amplified through the ‘itch → scratch → inflammation → (again) → itch → …’ vicious-cycle. Thus, pathomechanism-based management strategy could be provided accordingly–avoidance of triggering factor, repair of impaired barrier, control of skin inflammation, and decreasing desire for itch/scratch. Among them, controlling inflammation is thought to be most effective measure based on the clinical experiences, for skin inflammation, as one of key components in ‘itch-scratch-inflammation’ vicious-cycle, at the same time, is a crucial connecting link between OUTSIDE and INSIDE. However, individualized approach should be taken for patient per se. Finally, following topics may be future topics for doctors always hungry for new weapon against AD and patients suffering from this out-of-place (a-top-y) disease: central itch pathway—emerging new hero; neural sensitization - still in the Dark-Ages in terms of diagnosis and management; and scratch-just in its infancy
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참고문헌 (15)
참고문헌 신청
Akiyama T / 2011 / Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli / PLoS One 6 : e22665 ~
Bin Saif GA / 2012 / The pleasurability of scratching an itch: a psychophysical and topographical assessment / Br J Dermatol 166 : 981 ~ 985
Buddenkotte J / 2010 / Pathophysiology and therapy of pruritus in allergic and atopic diseases / Allergy 65 : 805 ~ 821
Charlesworth EN / 1994 / Practical approaches to the treatment of atopic dermatitis / Allergy Proc 15 : 269 ~ 274
Elias PM / 2008 / Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms / J Allergy Clin Immunol 121 : 1337 ~ 1343
Bin Saif GA / 2012 / The pleasurability of scratching an itch: a psychophysical and topographical assessment / Br J Dermatol 166 : 981 ~ 985
Buddenkotte J / 2010 / Pathophysiology and therapy of pruritus in allergic and atopic diseases / Allergy 65 : 805 ~ 821
Charlesworth EN / 1994 / Practical approaches to the treatment of atopic dermatitis / Allergy Proc 15 : 269 ~ 274
Elias PM / 2008 / Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms / J Allergy Clin Immunol 121 : 1337 ~ 1343
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