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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제4호
- 발행연도
- 2015.1
- 수록면
- 267 - 271 (5page)
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Purpose: Fractional exhaled nitric oxide (FeNO) is a maker of airway inflammation, and impedance of low frequency in the impulse oscillometry system (IOS) reflects small-airway obstruction. We investigated the association of the FeNO level with IOS parameters and spirometry results in asthma patients.
Methods: Fifty-eight children with asthma (60.3%, male), mean age 8.3 years (range, 4.5–16.0 years), were enrolled in the study. Reactance and resistance at 5 Hz with IOS, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and forced expiratory flow 25%–75% of the vital capacity (FEF25%-75%) with spirometry and FeNO were measured in all patients. The Z-score of spirometry and IOS parameters and the mean level of FeNO were used for correlation and regression analysis.
Results: FeNO was not significantly associated with height, age, or other demographic parameters. There was a statistically significant correlation between spirometry results and IOS measurements. The FeNO level was not significantly correlated with IOS variables. After adjusting for height, sex, atopic status, and the use of inhaled corticosteroid, the FeNO level showed significant correlations with Z-score of FEV1/FVC (P=0.037, adjusted R2=0.234).
Conclusion: FeNO was significantly correlated with Z-scores of FEV1/FVC, but not with IOS variables. Therefore, FeNO may be used to detect whole airway obstruction, but not small-airway obstruction.
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참고문헌 (20)
참고문헌 신청
Olaguibel Rivera JM / 2014 / Spirometric and exTable haled nitric oxide reference values in preschool children from the community of Navarra / J Investig Allergol Clin Immunol 24:169~176
Dweik RA / 2011 / An official ATS clinical practice guideline : interpretation of exhaled nitric oxide levels(FENO)for clinical applications / Am J Respir Crit Care Med 184:602~615
Smith AD / 2004 / Diagnosing asthma : comparisons between exhaled nitric oxide measurements and conventional tests / Am J Respir Crit Care Med 169:473~478
van der Wiel E / 2013 / Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma : a systematic review / J Allergy Clin Immunol 131:646~657
Scichilone N / 2013 / Assessing and accessing the small airways; implications for asthma management / Pulm Pharmacol Ther 26:172~179
Dweik RA / 2011 / An official ATS clinical practice guideline : interpretation of exhaled nitric oxide levels(FENO)for clinical applications / Am J Respir Crit Care Med 184:602~615
Smith AD / 2004 / Diagnosing asthma : comparisons between exhaled nitric oxide measurements and conventional tests / Am J Respir Crit Care Med 169:473~478
van der Wiel E / 2013 / Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma : a systematic review / J Allergy Clin Immunol 131:646~657
Scichilone N / 2013 / Assessing and accessing the small airways; implications for asthma management / Pulm Pharmacol Ther 26:172~179
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