지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 94 - 100 (7page)
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초록· 키워드
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Background and Purpose No previous studies have investigated the relationship betweenvarious anti-ganglioside antibodies and the clinical characteristics of Guillain-Barré syndrome(GBS) in Korea. The aim of this study was to determine the prevalence and types of anti-ganglioside antibodies in Korean GBS patients, and to identify their clinical significance.
Methods Serum was collected from patients during the acute phase of GBS at 20 universitybased hospitals in Korea. The clinical and laboratory findings were reviewed and compared withthe detected types of anti-ganglioside antibody.
Results Among 119 patients, 60 were positive for immunoglobulin G (IgG) or immunoglobulin M antibodies against any type of ganglioside (50%). The most frequent type was IgG anti-GM1 antibody (47%), followed by IgG anti-GT1a (38%), IgG anti-GD1a (25%), and IgG anti-GQ1b (8%) antibodies. Anti-GM1-antibody positivity was strongly correlated with the presenceof preceding gastrointestinal infection, absence of sensory symptoms or signs, and absence ofcranial nerve involvement. Patients with anti-GD1a antibody were younger, predominantlymale, and had more facial nerve involvement than the antibody-negative group. Anti-GT1a-antibody positivity was more frequently associated with bulbar weakness and was highly associated with ophthalmoplegia when coupled with the coexisting anti-GQ1b antibody. Despite the presence of clinical features of acute motor axonal neuropathy (AMAN), 68% of anti-GM1- oranti-GD1a-antibody-positive cases of GBS were diagnosed with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) by a single electrophysiological study.
Conclusions Anti-ganglioside antibodies were frequently found in the serum of KoreanGBS patients, and each antibody was correlated strongly with the various clinical manifestations. Nevertheless, without an anti-ganglioside antibody assay, in Korea AMAN is frequentlymisdiagnosed as AIDP by single electrophysiological studies.
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참고문헌 (26)
참고문헌 신청
Asbury AK / 1990 / Assessment of current diagnostic criteria for Guillain-Barre syndrome / Ann Neurol 27 (Suppl) : S21 ~ S24
Chiba A / 1992 / Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome / Ann Neurol 31 : 677 ~ 679
Hadden RD / 1998 / Electrophysiological classification of Guillain-Barresyndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barre Syndrome Tr
Ho TW / 1995 / Guillain-Barre syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies / Brain 118 (Pt 3) : 597 ~ 605
Ho TW / 1999 / Anti-GD1a antibody is associated with axonal but not demyelinating forms of Guillain-Barre syndrome / Ann Neurol 45 : 168 ~ 173
Chiba A / 1992 / Serum IgG antibody to ganglioside GQ1b is a possible marker of Miller Fisher syndrome / Ann Neurol 31 : 677 ~ 679
Hadden RD / 1998 / Electrophysiological classification of Guillain-Barresyndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barre Syndrome Tr
Ho TW / 1995 / Guillain-Barre syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies / Brain 118 (Pt 3) : 597 ~ 605
Ho TW / 1999 / Anti-GD1a antibody is associated with axonal but not demyelinating forms of Guillain-Barre syndrome / Ann Neurol 45 : 168 ~ 173
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