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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 297 - 304 (8page)
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초록· 키워드
오류제보하기
Neurologic defcits resulting from stroke remain largely intractable, which has prompted thousands of studies aimed at developing methods for treating these neurologic sequelae. Endogenous neurogenesis is also known to occur afer brain damage, including that due to cerebral infarction. Focusing on this process may provide a solution for treating neurologic defcits caused by cerebral infarction. Te phosphatidylinositol-3-kinase (PI3K) pathway is known to play important roles in cell survival, and many studies have focused on use of the PI3K pathway to treat brain injury afer stroke. Furthermore, since the PI3K pathway may also play key roles in the physiology of neural stem cells (NSCs), eliciting the appropriate activation of the PI3K pathway in NSCs may help to improve the sequelae of cerebral infarction. This review describes the PI3K pathway, its roles in the brain and NSCs afer cerebral infarction, and the therapeutic possibility of activating the pathway to improve neurologic defcits afer cerebral infarction.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Auger KR / 1989 / PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells / Cell 57 : 167 ~ 175
Chalecka-Franaszek E / 1999 / Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons / Proc Natl Acad Sc
Crowder RJ / 1998 / Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons /
Cuesto G / 2011 / Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons / J Neurosci 31 : 2721 ~ 2733
Del Zoppo GJ / 2009 / Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American
Chalecka-Franaszek E / 1999 / Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons / Proc Natl Acad Sc
Crowder RJ / 1998 / Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons /
Cuesto G / 2011 / Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons / J Neurosci 31 : 2721 ~ 2733
Del Zoppo GJ / 2009 / Expansion of the time window for treatment of acute ischemic stroke with intravenous tissue plasminogen activator: a science advisory from the American
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