지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 7 (7page)
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Antipsychotic drugs are limited in their efficacy by the relatively poor response of negative and cognitive symptoms of schizophrenia as well as by the substantial variability in response between patients. Pharmacogenetic studies have sought to identify the genetic factors that underlie the individual variability in response to treatment, with a past emphasis on dopamine and serotonin receptors as candidate genes. Few studies have separated effects on positive and negative symptoms, despite the established differences in response to drug treatment between these syndromes. Where this has been done most findings are consistent with the conclusion that dopamine receptor polymorphisms relate to positive symptom response, while negative symptom improvement is influenced by polymorphisms of genes involved in 5-HT neurotransmission. A wide range of polymorphisms in other candidate genes have been investigated, with some positive findings in those genes associated with glutamatergic transmission and/or risk factors for schizophrenia. However, there remains a lack of good replicated findings; furthermore there is little evidence to support drug-specific genetic associations with treatment response. While most past studies focused on single candidate genes, technology now permits genome-wide association studies with response to antipsychotics. Although not without major limitations, these “hypothesis-free” approaches are beginning to identify further important risk factors for treatment response. Again there is little consistency between various studies, although some of the polymorphisms identified are in genes involved in neurodevelopment, which is increasingly being recognized as important in the pathophysiology of schizophrenia.
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참고문헌 (22)
참고문헌 신청
Benmessaoud D. / 2008 / Excess of transmission of the G allele of the -1438A/G polymorphism of the 5-HT2A receptor gene in patients with schizophrenia responsive to antipsyc
Cipriani A. / 2011 / Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis / Lancet 378 : 1306 ~ 1315
Dolzan V. / 2008 / Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes / Prog Neuropsychopharmacol Biol
Hwang R. / 2010 / Effect of dopamine D3 receptor gene polymorphisms and clozapine tr-eatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Se
Lee HY. / 2009 / No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with ch-aracteristics and treatment response to atypical antipsychotic agents
Cipriani A. / 2011 / Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis / Lancet 378 : 1306 ~ 1315
Dolzan V. / 2008 / Acute antipyschotic efficacy and side effects in schizophrenia: association with serotonin transporter promoter genotypes / Prog Neuropsychopharmacol Biol
Hwang R. / 2010 / Effect of dopamine D3 receptor gene polymorphisms and clozapine tr-eatment response: exploratory analysis of nine polymorphisms and meta-analysis of the Se
Lee HY. / 2009 / No association of serotonin transporter polymorphism (5-HTTVNTR and 5-HTTLPR) with ch-aracteristics and treatment response to atypical antipsychotic agents
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