지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 192 - 199 (8page)
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초록· 키워드
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Objective We investigated possible association between depressive disorders and BDNF Val66Met and 5-HTTLPR. Brain derived neurotrophic factor (BDNF) gene and serotonin transporter (SLC6A4) gene are promising candidate genes for depressive disorders. It has been suggested that BDNF promotes the survival and differentiation of serotonergic neurons and that serotonergic transmission exerts powerful control over BDNF gene expression.
Methods Final analyses were performed on 186 patients with depressive disorders and 1032 controls. Val66Met polymorphism of BDNF gene and 5-HTTLPR polymorphism of serotonin transporter gene were genotyped and allele and genotypic associations on the diagnosis of depression and age at onset of depression were analyzed.
Results The 5-HTTLPR was positively associated with depressive affected status in the total sample and in females (p=0.038 for allelewise, p=0.015 for genotype-wise associations), but, not in males. The BDNF Val66Met showed no association with depression. BDNF Val66Met and 5-HTTLPR alone were not associated with age at onset of depression. Additional analysis on the interaction between BDNF Val66Met and 5-HTTLPR found a significant association with age at onset of depression in the entire patient group. This association was also found in the female but not in the male patient group. None of the positive results survived Bonferroni correction for multiple testing.
Conclusion This result suggested that BDNF Val66Met and 5-HTTLPR may contribute to depressive disorders in a complex way and that the genetic effect could differ by gender. Further studies with large number of patients will be necessary.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Autry AE / 2012 / Brain-derived neurotrophic factor and neuropsychiatric disorders / Pharmacol Rev 64 : 238 ~ 258
Bun-Hee Lee / 2010 / The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment / PSYCHIATRY INVESTIGATION 7 (4) : 231 ~ 235
Caspi A / 2003 / Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene / Science 301 : 386 ~ 389
Chen L / 2008 / Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis / Am J Med Genet Part B Neuropsychiatr Genet 147B : 814
Clarke H / 2010 / Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis / Psychol Med 40 : 1767 ~ 1778
Bun-Hee Lee / 2010 / The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment / PSYCHIATRY INVESTIGATION 7 (4) : 231 ~ 235
Caspi A / 2003 / Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene / Science 301 : 386 ~ 389
Chen L / 2008 / Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis / Am J Med Genet Part B Neuropsychiatr Genet 147B : 814
Clarke H / 2010 / Association of the 5-HTTLPR genotype and unipolar depression: a meta-analysis / Psychol Med 40 : 1767 ~ 1778
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