지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 186 - 191 (6page)
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초록· 키워드
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Objective DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations.
Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis.
Methods Two hundred and thirteen Caucasian drug-naïve patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales.
Other clinical and socio-demographic variables were recorded to rule out possible confounding effects.
Results Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers.
Conclusion DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.
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등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Szeszko PR / 2008 / DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia / Biol Psychol 79:103~110
DeRosse P / 2007 / Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia / Biol Psychiatry 61:1208~1210
Crespo-Facorro B / 2006 / A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode non-affective psychosis / J Clin Psychiatry 67:1511~1521
Andreasen NC / 1984 / Scale for the Assessment of Positive Symptoms (SAPS) / University of Iowa
Andreasen NC / 1983 / Scale for the Assessment of Negative Symptoms (SANS) / University of Iowa
DeRosse P / 2007 / Disrupted in schizophrenia 1 genotype and positive symptoms in schizophrenia / Biol Psychiatry 61:1208~1210
Crespo-Facorro B / 2006 / A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode non-affective psychosis / J Clin Psychiatry 67:1511~1521
Andreasen NC / 1984 / Scale for the Assessment of Positive Symptoms (SAPS) / University of Iowa
Andreasen NC / 1983 / Scale for the Assessment of Negative Symptoms (SANS) / University of Iowa
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