지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 430 - 436 (7page)
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초록· 키워드
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Objective Methamphetamine (MA) use rates in the United States (US) have consistently demonstrated geographical variation and have been higher in the West and Midwest. This uneven pattern of use could be explained by regional differences in MA manufacturing and distribution, but may also result from differences in altitude. The hypobaric hypoxia found at high altitude alters neurotransmitter synthesis in the brain, which may contribute to MA use. The present study investigated the relationship between mean altitude and MA use rate in the 48 contiguous US states and the District of Columbia.
Methods State-level estimates of past year MA use were extracted from the National Survey on Drug Use and Health report. The mean altitude of each state was calculated using the Shuttle Radar Topography Mission altitude data set.
Results There was a significant positive correlation between mean state altitude and MA use rate (r=0.66, p<0.0001). Multivariate linear regression analysis showed that altitude remained a significant predictor for MA use rate (β=0.36, p=0.02), after adjusting for age, ethnicity, education, socioeconomic level, employment, MA laboratory incidents, subpopulations, and other substance use.
Conclusion Altitude appears to a possible contributing factor for regional variation of MA use in the US. Further studies will be required to determine biological changes in neurotransmission resulting from chronic mild hypoxia at high altitude in MA users.
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등록된 정보가 없습니다.
참고문헌 (59)
참고문헌 신청
Akimoto K / 1990 / Enhanced extracellular dopamine level may be the fundamental neuropharmacological basis of cross-behavioral sensitization between methamphetamine and cocaine - an in vivo dialysis study in freely moving rats / Brain Res 507:344~346
Bardo MT / 1998 / Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens / Crit Rev Neurobiol 12:37~67
White FJ / 1998 / Neuroadaptations involved in amphetamine and cocaine addiction / Drug Alcohol Depend 51:141~153
Volkow ND / 2007 / Dopamine in drug abuse and addiction: results of imaging studies and treatment implications / Arch Neurol 64:1575~1579
Davidson C / 2005 / Acute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences / Neurochem Int 46:189~203
Bardo MT / 1998 / Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens / Crit Rev Neurobiol 12:37~67
White FJ / 1998 / Neuroadaptations involved in amphetamine and cocaine addiction / Drug Alcohol Depend 51:141~153
Volkow ND / 2007 / Dopamine in drug abuse and addiction: results of imaging studies and treatment implications / Arch Neurol 64:1575~1579
Davidson C / 2005 / Acute and chronic continuous methamphetamine have different long-term behavioral and neurochemical consequences / Neurochem Int 46:189~203
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