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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 263 - 267 (5page)
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초록· 키워드
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ObjectiveaaRestless legs syndrome (RLS) is a distressing sleep disorder to which individuals appear to be genetically predisposed. In the present study, we assumed that antipsychotic-induced RLS symptoms were attributable to differences in individual genetic susceptibility, and investigated whether MEIS1, a promising candidate gene, was associated with antipsychotic-induced RLS symptoms in schizophrenia patients.
MethodsaaAll subjects were diagnosed with schizophrenia by board-certified psychiatrists using the Korean version of the Structured Clinical Interview for DSM-IV. We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Genotyping was performed for the rs2300478 and rs6710341 polymorphisms of the MEIS1 gene.
ResultsaaWe divided subjects into RLS symptom (n=96) and non-symptom (n=94) groups. There was no significant between-group difference in the genotype or allele frequencies of the two polymorphisms investigated, nor in the frequency of the rs2300478-rs6710341 haplotype.
ConclusionaaOur data do not suggest that the rs2300478 and rs6710341 polymorphisms of the MEIS1 gene are associated with the core symptoms of antipsychotic-induced RLS in schizophrenia; different genetic mechanisms may underlie antipsychotic-induced vs. primary RLS.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Chen S / 2004 / Genomewide linkage scan identifies a novel susceptibility locus for RLS on chromosome 9p / Am J Hum Genet 74 : 876 ~ 885
Desautels A / 2005 / Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity / Arch Neurol 62 : 591 ~ 596
Horiguchi J / 1999 / Nocturnal eating/drinking syndrome and neuroleptic-induced restless syndrome / Int Clin Psychopharmacol 14 : 33 ~ 36
Jung JS / 2014 / Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia / Chronobiol Int 31 : 838 ~ 844
Kang SG / 2007 / Characteristics and clinical correlates of restless legs syndrome in schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 31 : 1078 ~ 1083
Desautels A / 2005 / Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity / Arch Neurol 62 : 591 ~ 596
Horiguchi J / 1999 / Nocturnal eating/drinking syndrome and neuroleptic-induced restless syndrome / Int Clin Psychopharmacol 14 : 33 ~ 36
Jung JS / 2014 / Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizophrenia / Chronobiol Int 31 : 838 ~ 844
Kang SG / 2007 / Characteristics and clinical correlates of restless legs syndrome in schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 31 : 1078 ~ 1083
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