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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives ZZThe aims of this study were to examine the relationship between obesity and psychopathology of inpatients with schizophrenia. MethodsZZEighty four inpatients with schizophrenia and 81 control subjects were recruited. Height and weight were measured for calculation of body mass index (BMI). Symptom severity scales [Positive and Negative Syndrome Scale (PANSS), Brief Psychiatric Rating Scale] and Global Assessment of Functioning Scale (GAF) were conducted in all patients. Comorbid medical conditions, years of education, smoking status, age of onset, duration of illness, and medication history were collected. ResultsZZPatients with schizophrenia had significantly higher BMI and ratio of obesity than control subjects. Among patients, obese patients scored lower on symptom severity scales and better on functional assessment than not obese patients. Multiple regression analysis revealed an association of late onset and being obese with lower PANSS total score and better GAF score in patients. Late onset and being female were inversely related with negative symptom score. The type and dose of antipsychotics showed no association with obesity. ConclusionZZThe results of this study indicate that patients with schizophrenia are likely to be more obese. Some characteristics of patients with less severe psychopathology, such as late onset, being obese, were coincident with the result of previous studies. In addition, the result showing that the heavier the weight of patients, the lower severity of symptoms was repeatedly reported in previous studies. The type and dose of antipsychotics were not associated with obesity. These results prompt further investigation of the relationship among schizophrenia, antipsychotics, and weight gain.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
American Diabetes Association / 2004 / Consensus development conference on antipsychotic drugs and obesity and diabetes / Diabetes Care 27 : 596 ~ 601
Bai YM / 2006 / Association of initial antipsychotic response to clozapine and long-term weight gain / Am J Psychiatry 163 : 1276 ~ 1279
Basson BR / 2001 / Factors influencing acute weight change in patients with schizophrenia treated with olanzapin
Cohn T / 2004 / Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome / Can J Psychiatry 49 : 753 ~ 760
Czobor P / 2002 / Antipsychotic-induced weight gain and therapeutic response:a differential association / J Clin Psychopharmacol 22 : 244 ~ 251
Bai YM / 2006 / Association of initial antipsychotic response to clozapine and long-term weight gain / Am J Psychiatry 163 : 1276 ~ 1279
Basson BR / 2001 / Factors influencing acute weight change in patients with schizophrenia treated with olanzapin
Cohn T / 2004 / Characterizing coronary heart disease risk in chronic schizophrenia: high prevalence of the metabolic syndrome / Can J Psychiatry 49 : 753 ~ 760
Czobor P / 2002 / Antipsychotic-induced weight gain and therapeutic response:a differential association / J Clin Psychopharmacol 22 : 244 ~ 251
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