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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제9권 제3호
발행연도
2012.1
수록면
263 - 268 (6page)

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Objective The primary aim of this study was to compare electronic monitoring with other measures of adherence to Osmotic-controlled Release Oral delivery System methylphenidate in children with attention-deficit hyperactivity disorder (ADHD). The secondary aim was to analyze the relationships between adherence and clinical factors, including ADHD symptoms. Methods Thirty-nine children diagnosed with ADHD were monitored for adherence to medication over the course of eight weeks. Medication adherence was assessed using the Medication Event Monitoring System (MEMS), which is a bottle cap with a microprocessor that records all instances and times that the bottle is opened; patient self-report; clinician rating; and pill count. Information, including demographic and clinical characteristics, symptom rating scale, and psychological test results, were also collected. The relationships between adherence and clinical factors, including ADHD rating scores of baseline and of the changes, were assessed. Results The rate of non-adherence measured by the MEMS was found to be 46.2%, which was considerably higher than those of the patient self-report (17.9%), clinician rating (31.7%), and pill count (12.8%) of non-adherence. The rate of adherence measured by the MEMS was not significantly associated with baseline symptom severity or symptom changes over the eight weeks, although non-adherent group showed more severe baseline symptoms and inferior improvement. Conclusion Adherence as measured by the MEMS showed a discrepancy with other measures of adherence in patients with ADHD. The symptom severity and level of improvement were not related to adherence with MEMS. Further studies are needed to evaluate the variables that may impact medication adherence in children with ADHD.
#Attention-deficit hyperactivity disorder #Adherence #Medication Event Monitoring System #Symptoms.

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참고문헌 (25)

참고문헌 신청
Adler LD. / 2010 / Review of medication adherence in children and adults with ADHD / Postgrad Med 122 : 184 ~ 191 google schola Brown RT. / 1985 / Adherence to methylphenidate therapy in a pediatric population: a preliminary investigation / Psychopharmacol Bull 21 : 28 ~ 36 google schola Byerly M. / 2005 / A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia / Psychiatry Res 133 : 129 ~ 133 google schola Charach A. / 2004 / Stimulant treatment over five years: adherence, effectiveness, and adverse effects / J Am Acad Child Adolesc Psychiatry 43 : 559 ~ 567 google schola Charach A. / 2008 / Documenting adherence to psychostimulants in children with ADHD / J Can Acad Child Adolesc Psychiatry 17 : 131 ~ 136 google schola

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