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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,188 - 1,202 (15page)
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ObjectiveaaThis study protocol aims to determine, using a rigorous approach in patients with bipolar disorder (BD) and non-seasonal major depressive episode (MDE), the characteristics of bright light therapy (BLT) administration (duration, escalation, morning and mid-day exposures) depending on the tolerance (hypomanic symptoms). MethodsaaPatients with BD I or II and treated by a mood stabilizer are eligible. After 1 week of placebo, patients are randomized between either morning or mid-day exposure for 10 weeks of active BLT with glasses using a dose escalation at 7.5, 10, 15, 30 and 45 minutes/ day. A further follow-up visit is planned 6 months after inclusion. Patients will be included by cohorts of 3, with at least 3 days of delay between them, and 1 week between cohorts. If none meet a dose limiting toxicity (DLT; i.e hypomanic symptoms), the initiation dose of the next cohort will be increased. If one patient meet a DLT, an additionnal cohort will start at the same dose. If 2 or 3 patients meet a DLT, from the same cohort or from two cohorts at the same dose initiation, the maximum tolerated dose is defined. This dose escalation will also take into account DLTs observed during the intra-subject escalation on previous cohorts, with a “Target Ceiling Dose” defined if 2 DLTs occured at a dose. DiscussionaaUsing an innovative and more ergonomic device in the form of glasses, this study aims to better codify the use of BLT in BD to ensure a good initiation and tolerance.
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참고문헌 (55)
참고문헌 신청
Collins PY / 2011 / Grand challenges in global mental health / Nature 475:27~30
Merikangas KR / 2007 / Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication / Arch Gen Psychiatry 64:543~552
Chesney E / 2014 / Risks of all-cause and suicide mortality in mental disorders: a meta-review / World Psychiatry 13:153~160
Hayes JF / 2015 / A systematic review and meta-analysis of premature mortality in bipolar affective disorder / Acta Psychiatr Scand 131:417~425
Geddes JR / 2013 / Treatment of bipolar disorder / Lancet 381:1672~1682
Merikangas KR / 2007 / Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication / Arch Gen Psychiatry 64:543~552
Chesney E / 2014 / Risks of all-cause and suicide mortality in mental disorders: a meta-review / World Psychiatry 13:153~160
Hayes JF / 2015 / A systematic review and meta-analysis of premature mortality in bipolar affective disorder / Acta Psychiatr Scand 131:417~425
Geddes JR / 2013 / Treatment of bipolar disorder / Lancet 381:1672~1682
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