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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,121 - 1,129 (9page)
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초록· 키워드
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Objective Categorical syndrome such as schizophrenia could be the complex of many continuous mental structure phenotypes including several personality development/degeneration dimensions. This is the study to search heritability and familiality of MMPI personality dimensions in the Korean schizophrenic LD (Linkage Disequilibrium) families. Methods We have recruited 204 probands (with schizophrenia) with their parents and siblings whenever possible. We have used MMPI questionnaires for measuring personality and symptomatic dimensions. Heritabilities of personality dimensions in total 543 family members were estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). Personality dimensions in total family members were compared with those in 307 healthy unrelated controls for measuring the familialities using ANOVA analysis. Results Seven of the 10 MMPI variables were significantly heritable and were included in the subsequent analyses. The three groups (control, unaffected 1st degree relative, case) were found to be significantly different with the expected order of average group scores for all heritable dimensions. Conclusion Our results show that the aberrations in several personality dimensions could form the complexity of schizophrenic syndrome as a result of genetic-environment coactions or interactions in spite of some limitations (recruited family, phenotyping).
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등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
McGuffin P / 1994 / The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia? / Br J Psychiatry 164:593~599
Bachmann RF / 2005 / Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics / Mol Neurobiol 32:173~202
Bartels SJ / 2003 / Medicare and medicaid costs for schizophrenia patients by age cohort compared with costsfor depression, dementia, and medically ill patients / Am J Geriatr Psychiatry 11:648~657
Bauer M / 2002 / NIMH Affective Disorders Workgroup. Bipolar disorder / Ment Health Serv Res 4:225~229
Shih RA / 2004 / A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders / Int Rev Psychiatry 16:260~283
Bachmann RF / 2005 / Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics / Mol Neurobiol 32:173~202
Bartels SJ / 2003 / Medicare and medicaid costs for schizophrenia patients by age cohort compared with costsfor depression, dementia, and medically ill patients / Am J Geriatr Psychiatry 11:648~657
Bauer M / 2002 / NIMH Affective Disorders Workgroup. Bipolar disorder / Ment Health Serv Res 4:225~229
Shih RA / 2004 / A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders / Int Rev Psychiatry 16:260~283
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