지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives This study is to assess the effects of adjuvant therapy of atypical antipsychotics on the change clinical symptoms in patients with major depressive disorder.
Methods We conducted a chart review of patients, who visited a university hospital. Ninety seven patients were divided into two groups : patients with adjuvant use of antipsychotics with antidepressants (AD+AAP ; n=32) and patients with only antidepressants (AD ; n=65). We compared and analyzed three clinical domains including depressive symptoms, anxiety symptoms and sleep qualities between two groups. Depressive symptoms, Anxiety symptoms, and sleep pattern were evaluated by Beck’s Depression Inventory (BDI), Beck’s Anxiety Inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI) at baseline (first day of admission) and 1 year later.
Results During 1 year, the BDI scores of AD+AAP group has been greatly decreased, compared to AD group (F=5.87, p=0.02). In the comparison of patients with severe symptoms of major depressive disorder (BDI score >21), there was significant difference in the change of BDI score between AD+AAP and AD (F=4.14, p=0.04). After 1 year, there were no significant differences in BAI score change (F=0.51, p=0.47), PSQI score change (F=0.89, p=0.35) between two group. However, the duration of adjunctive therapy and the type of atypical antipsychotics would not impact the results.
Conclusion Current study suggested that adjuvant therapy of atypical antipsychotics would be effective on depressive symptoms in patients with severe major depressive disorder, compared to the treatment with antidepressants alone.
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참고문헌 (24)
참고문헌 신청
Andreescu C / 2007 / Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features / J Clin Psychiatry 68 : 194 ~ 200
Beck AT / 1961 / An inventory for measuring depression / Arch Gen Psychiatry 4 : 561 ~ 571
Buysse DJ / 1989 / The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research / Psychiatry Res 28 : 193 ~ 213
Davidson JR / 2010 / Major depressive disorder treatment guidelines in America and Europe / J Clin Psychiatry 71 (1) : 04 ~
Gao K / 2006 / Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review / J Clin Psychiatry 67 : 1327 ~ 1340
Beck AT / 1961 / An inventory for measuring depression / Arch Gen Psychiatry 4 : 561 ~ 571
Buysse DJ / 1989 / The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research / Psychiatry Res 28 : 193 ~ 213
Davidson JR / 2010 / Major depressive disorder treatment guidelines in America and Europe / J Clin Psychiatry 71 (1) : 04 ~
Gao K / 2006 / Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review / J Clin Psychiatry 67 : 1327 ~ 1340
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