지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 130 - 133 (4page)
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초록· 키워드
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Objective Psychiatric disorders such as depression, anxiety and alcohol dependence are associated with serotonin metabolism. We assessed the methylation level of the serotonin transporter (5-HTT) promoter region in control and alcohol dependent patients.
Methods Twenty seven male patients who met the Diagnostic and Statistical Manual of Mental Disorder IV (DSM-IV) criteria for alcohol dependence were compared with fifteen controls. Polymerase chain reaction (PCR) assays of bisulfate-modified DNA were designed to amplify a part of the CpG island in the 5HTT gene. Pyrosequencing was performed and the methylation level at seven CpG island sites was measured.
Results We found no differences in the methylation patterns of the serotonin transporter linked promoter region (5-HTTLPR) between alcohol-dependent and control subjects.
Conclusion Our negative finding may be because 5-HTT epigenetic variation may not affect the expression for 5-HTT or there may be other methylation site critical for its expression. To find out more conclusive result, repeating the study in more methylation sites with a larger number of samples in a well-controlled setting is needed.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorder / American Psychiatric Press
Bradley SL / 2005 / Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription / Am J Med Genet B Neuropsychiatr Genet 136B : 58 ~ 61
Brown GW / 2008 / Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction / J Affect Disord 111 : 1
Conroy J / 2004 / Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population / Mol Psychiatry 9 : 587 ~ 593
Feinn R / 2005 / Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence / Am J Med Genet B Neuropsychiatr Genet
Bradley SL / 2005 / Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription / Am J Med Genet B Neuropsychiatr Genet 136B : 58 ~ 61
Brown GW / 2008 / Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction / J Affect Disord 111 : 1
Conroy J / 2004 / Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population / Mol Psychiatry 9 : 587 ~ 593
Feinn R / 2005 / Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence / Am J Med Genet B Neuropsychiatr Genet
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