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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 523 - 531 (9page)
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초록· 키워드
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ObjectiveaaBrain-derived neurotrophic factor (BDNF) is investigated in depression related to medical disorders and its secretion is influenced by epigenetic factors. We investigated the association between BDNF promoter methylation and depression following mastectomy for breast cancer.
MethodsaaIn total, 309 patients with breast cancer were evaluated 1 week after mastectomy, and 244 (79%) were followed up 1 year later. Depression was diagnosed (major or minor depressive disorder) according to DSM-IV criteria and depression severity was estimated by Montgomery-Asberg Depression Rating Scale (MADRS). We assessed BDNF promoter methylation using leukocyte DNA. The effects of BDNF methylation on depression diagnosis and severity were investigated using multivariate logistic and linear regression models, respectively. The two-way interaction between BDNF methylation and the val66met polymorphism on depression was also evaluated using multivariate logistic regression models.
ResultsaaHigher BDNF methylation was independently associated with depression diagnosis and with more severe symptoms at both 1 week and 1 year after mastectomy. No significant methylation-genotype interactions were found.
ConclusionaaA role for BDNF in depression related to breast cancer was supported. Indeed, the association between depression and BDNF methylation may be useful for identifying patients who are at high risk for depression and for suggesting directions for promising drug research.
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참고문헌 (24)
참고문헌 신청
Bower J / 2008 / Behavioral symptoms in patients with breast cancer and survivors / J Clin Oncol 26 : 768 ~ 777
Bozzini S / 2009 / Coronary artery disease and depression: possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms / Int J Mol Med 24
Burgess C / 2005 / Depression and anxiety in women with early breast cancer: five year observational cohort study / BMJ 330 : 702 ~
Caspi A / 2010 / Genetic Sensitivity to the Environment: the Case of the serotonin transporter gene and its implications for studying complex diseases and traits / Am J Psyc
Egan MF / 2003 / The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function / Cell 112 : 257 ~ 269
Bozzini S / 2009 / Coronary artery disease and depression: possible role of brain-derived neurotrophic factor and serotonin transporter gene polymorphisms / Int J Mol Med 24
Burgess C / 2005 / Depression and anxiety in women with early breast cancer: five year observational cohort study / BMJ 330 : 702 ~
Caspi A / 2010 / Genetic Sensitivity to the Environment: the Case of the serotonin transporter gene and its implications for studying complex diseases and traits / Am J Psyc
Egan MF / 2003 / The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function / Cell 112 : 257 ~ 269
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