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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 583 - 589 (7page)
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초록· 키워드
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Alzheimer’s disease (AD) without cure remains as a serious health issue in the modern society. The major neuropathological alterations in AD are characterized by chronic neuroinflammation and neuronal loss due to neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau, plaques of β-amyloid (Aβ) and various metabolic dysfunctions. Due to the multifaceted nature of AD pathology and our limited understanding on its etiology, AD is difficult to be treated with currently available pharmaceuticals. This unmet need, however, could be met with stem cell technology that can be engineered to replace neuronal loss in AD patients. Although stem cell therapy for AD is only in its development stages, it has vast potential uses ranging from replacement therapy to disease modelling and drug development.
Current progress with stem cells in animal model studies offers promising results for the new prospective treatment for AD. This review will discuss the characteristics of AD, current progress in stem cell therapy and remaining challenges and promises in its development.
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등록된 정보가 없습니다.
참고문헌 (100)
참고문헌 신청
Zhagn L / 2014 / Alzheimer and the discovery of Alzheimer’s disease / Zhonghua Yi Shi Za Zhi 44:288~290
Francis PT / 2005 / The interplay of neurotransmitters in Alzheimer’s disease / CNS Spectr 10(11 Suppl 18):6~9
Marczynski TJ / 1998 / GABAergic deafferentation hypothesis of brain aging and Alzheimer’s disease revisited / Brain Res Bull 45:341~379
Palmer AM / 1990 / Is the neuronal basis of Alzheimer’s disease cholinergic or glutamatergic? / FASEB J 4:2745~2752
Derouesne C / 2008 / Alzheimer and Alzheimer’s disease: the present enlighted by the past. An historical approach / Psychol Neuropsychiatr Vieil 6:115~128
Francis PT / 2005 / The interplay of neurotransmitters in Alzheimer’s disease / CNS Spectr 10(11 Suppl 18):6~9
Marczynski TJ / 1998 / GABAergic deafferentation hypothesis of brain aging and Alzheimer’s disease revisited / Brain Res Bull 45:341~379
Palmer AM / 1990 / Is the neuronal basis of Alzheimer’s disease cholinergic or glutamatergic? / FASEB J 4:2745~2752
Derouesne C / 2008 / Alzheimer and Alzheimer’s disease: the present enlighted by the past. An historical approach / Psychol Neuropsychiatr Vieil 6:115~128
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