지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 354 - 360 (7page)
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초록· 키워드
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Objective Preliminary data indicate that predominant positive symptoms are predictive of subsequent treatment response, while negative and cognitive symptoms are associated with poor outcome. Purpose of the present study was to investigate the relation between the predominant clinical dimension, duration of illness and acute antipsychotic response in a sample of schizophrenic inpatients.
Methods Fifty-one schizophrenic inpatients, receiving an antipsychotic mono-therapy, were dimensionally assessed at the admission in the Acute Psychiatric Unit of the University of Milan. Treatment response was selected as parameter of outcome and defined as a reduction >50% of baseline total The Positive and Negative Syndrome Scale (PANSS) score. Demographic and clinical variables between responders and non-responders were compared using one-way analysis of variance for continuous variables and χ2 test for dichotomous ones. Binary logistic regression was performed to find if dimensional scores and duration of illness were associated with acute antipsychotic response.
Results A longer duration of illness was found in non-responders respect to responders (15.61 years vs. 8.28 years)(F=4.98, p=0.03).
Higher scores on PANSS positive sub-scale (OR=1.3, p=0.03), lower scores on cognitive PANSS scores (OR=0.75, p=0.05) and shorter duration of illness (OR=0.93, p=0.04) were found to be predictive of acute antipsychotic response.
Conclusion These preliminary results show that a long duration of illness as well as a more severe cognitive impairment is predictive of treatment non-response, indicating a worse outcome for chronic patients with predominant cognitive symptoms.
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참고문헌 (22)
참고문헌 신청
[학
Altamura AC. / 2007 / Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment / Int Clin Psychopharmacol 22 : 249 ~ 267
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders, 4th Edition / American Psychiatric Association
Bilder RM. / 2002 / Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder / Am J P
Breier A. / 1999 / The psychosis of schizophrenia: prevalence, response to atypical antipsychotics, and prediction of outcome / Biol Psychiatry 46 : 361 ~ 364
Altamura AC. / 2007 / Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment / Int Clin Psychopharmacol 22 : 249 ~ 267
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders, 4th Edition / American Psychiatric Association
Bilder RM. / 2002 / Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder / Am J P
Breier A. / 1999 / The psychosis of schizophrenia: prevalence, response to atypical antipsychotics, and prediction of outcome / Biol Psychiatry 46 : 361 ~ 364
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