지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives：Although genotype of endothelial nitric oxide synthase has been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the nature of endothelial nitric oxide synthase in Korean schizophrenic patients, and compare it with healthy control group in terms of distribution of e genotype and allele frequency of endothelial nitric oxide synthase.
Methods：Using polymerase chain reaction and amplified refractory mutation system, endothelial nitric oxide synthase genotypes were identified in 77 schizophrenics and 121 healthy controls.
Results：1) When genotypes of endothelial nitric oxide synthase were classified as a/a, a/b, b/b, there was no statistical difference in genotypes between the two groups. 2) In terms of allele frequency, there was also no statistical difference between the two groups.
Conclusion：These results suggest that endothelial nitric oxide synthase gene seem to be unrelated to the pathogenesis of schizophrenia in Korean population. (J Korean Neuropsychiatr Assoc 2004;43(1):18-22)
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참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)
/ 1991 / Nitric oxide:physiology,pathophysiology,and pharmacology 43 : 109 ~ 142
/ 1992 / A novel neuronal messengermolecule in brain:the free radical,nitric oxide 32 : 297 ~ 311
/ 1993 / A synaptic model of memory:long-termpotentiation in the hippocampus 361 : 31 ~ 39
/ 1993 / Distorted distribution of nicotinamide-adenine dinucleotide phosphatediaphoraseneurons in temporal lobe of schizophrenics implies anomalouscortical development 50 :
/ 1991 / Nitric oxide:physiology,pathophysiology,and pharmacology 43 : 109 ~ 142
/ 1992 / A novel neuronal messengermolecule in brain:the free radical,nitric oxide 32 : 297 ~ 311
/ 1993 / A synaptic model of memory:long-termpotentiation in the hippocampus 361 : 31 ~ 39
/ 1993 / Distorted distribution of nicotinamide-adenine dinucleotide phosphatediaphoraseneurons in temporal lobe of schizophrenics implies anomalouscortical development 50 :
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