지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 421 - 424 (4page)
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초록· 키워드
오류제보하기
Memantine and other glutamatergic agents have been currently investigated in some off-label indications due to glutamatergic involvement in several psychoneurological disorders. We assumed that memantine similarly to ketamine may positively influence mood, moreover having a potential to improve cognition and general quality of life. We report a case of a 49-year-old male hospitalized during a manic and a subsequent moderate depressive episode. After an ineffective use of lithium, olanzapine and antidepressive treatment with mianserin, memantine was added up to 20 mg per day for 10 weeks. The mental state was assessed using the Hamilton Depression Rating Scale, the Young Mania Rating Scale, the Hamilton Anxiety Scale, the Clinical Global Inventory, the World Health Organization Quality of Life Scale and psychological tests. After 10 weeks the patient achieved a partial symptomatic improvement in mood, anxiety and quality of sleep, but his activity remained insufficient. We also observed an improvement in the parameters of cognitive functioning and quality of life. There was neither significant mood variations during the memantine use nor mood changes after its termination. No significant side effects were noted during the memantine treatment. We conclude that using memantine in bipolar depression may improve mood, cognitive functioning and quality of life.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Koukopoulos A / 2010 / Antimanic and mood-stabilizing effect of memantine as an augmenting agent in treatment-resistant bipolar disorder / Bipolar Disord 12:348~349
Witkin JM / 2009 / New approaches to the pharmacological management of major depressive disorder / Adv Pharmacol 57:347~379
Enz R. / 2012 / Metabotropic glutamate receptors and interacting proteins: evolving drug targets / Curr Drug Targets 13:145~156
/ / Ebixa (Memantine) Monograph
Agarwal V / 2009 / Memantine in the management of a clinically challenging case of bipolar disorder / Indian J Psychiatry 51 : 137 ~ 138
Witkin JM / 2009 / New approaches to the pharmacological management of major depressive disorder / Adv Pharmacol 57:347~379
Enz R. / 2012 / Metabotropic glutamate receptors and interacting proteins: evolving drug targets / Curr Drug Targets 13:145~156
/ / Ebixa (Memantine) Monograph
Agarwal V / 2009 / Memantine in the management of a clinically challenging case of bipolar disorder / Indian J Psychiatry 51 : 137 ~ 138
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