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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 242 - 250 (9page)
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Purpose The current study was conducted in order to evaluate the clinical outcome of radical radiotherapy (RT) with or without chemotherapy for elderly patients with stage III non-small cell lung cancer (NSCLC).
Materials and Methods Between 1990 and 2010, 125 patients, aged 70 years or more, received radical RT with or without chemotherapy for treatment of stage III NSCLC. We reviewed the patients’prognostic factors, including comorbidities. Comorbidity status was evaluated using a simplified comorbidity score (SCS). Of the patients reviewed, 82 received radical RT alone,whereas the other 43 patients underwent chemoradiotherapy (CRT). A platinum-based chemotherapy regimen was most commonly used (42/43).
Results The two-year overall-survival (OS) and progression-free survival (PFS) rates were 32.2%and 21.8%, respectively. SCS was the independent prognostic factor for OS. In the frail elderly subgroup with a SCS of ≥10, CRT demonstrated a significant difference in PFS, but not in OS. In contrast, OS and PFS following CRT were significantly superior to RT in the fit elderly subgroup with a SCS of <10. The incidence of severe pulmonary toxicities in the frail elderly subgroup was significantly higher than that in the fit elderly subgroup.
Conclusion Multiple comorbidities evaluated according to the SCS are related to poor OS in elderly patients with stage III NSCLC. CRT improved clinical outcome when compared to RT in the fit elderly subgroup, however, the gain from this treatment was negated in the frail elderly subgroup with multiple comorbidities. Therefore, evaluation of comorbidity is necessary in order to determine whether chemotherapy should be combined with RT in elderly patients with stage III NSCLC.
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참고문헌 (23)
참고문헌 신청
Liu JJ / 2012 / Comprehensive geriatric assessment and its clinical impact in oncology / Clin Geriatr Med 28:19~31
Dancey J / 1997 / The National Cancer Institute of Canada Clinical Trials Group / Qual Life Res 6:151~158
Schneeweiss S / 2000 / Use of comorbidity scores for control of confounding in studies using administrative databases / Int J Epidemiol 29:891~898
Atagi S / 2012 / Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with nonsmall-cell lung cancer : a randomised, controlled, phase 3 trial
Auperin A / 2006 / Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer(NSCLC) : a meta-analysis of individua
Dancey J / 1997 / The National Cancer Institute of Canada Clinical Trials Group / Qual Life Res 6:151~158
Schneeweiss S / 2000 / Use of comorbidity scores for control of confounding in studies using administrative databases / Int J Epidemiol 29:891~898
Atagi S / 2012 / Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with nonsmall-cell lung cancer : a randomised, controlled, phase 3 trial
Auperin A / 2006 / Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer(NSCLC) : a meta-analysis of individua
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