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자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제46권 제1호
발행연도
2014.1
수록면
41 - 47 (7page)

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PurposeThere are various lymph node-based staging systems. Nevertheless, there is debateover the use of parameters such as the number of involved lymph nodes and thelymph node ratio. As a possible option, the distribution of metastatic lymph nodesmay have a prognostic significance in rectal cancer. This study is designed to evaluatethe impact of distribution-weighted nodal staging on oncologic outcome in rectalcancer. Materials and MethodsFrom a prospectively maintained colorectal cancer database of our institution, a totalof 435 patients who underwent a curative low anterior resection for mid and upperrectal cancer between 1995 and 2004 were enrolled. Patients were divided into 3groups according to the location of apical metastatic nodes. A location-weighted prognosticscore was calculated by a scoring model using a logistic regression test forlocation based-statistical weight to number of lymph nodes. All cases were categorizedin quartiles from lymph node I to lymph node IV using this protocol. ResultsThe location of lymph node metastasis was an independent factor that wasassociated with a poor prognostic outcome (p<0.001). Based on this result, thelocation-weighted-nodal prognostic scoring model did not show lesser significantresults (p<0.0001) in both overall survival and cancer-free survival analyses. ConclusionThe location of apical nodes among the metastatic nodes does not have a lessersignificant impact on oncologic result in patients with advanced rectal cancer. Alocation-weighted prognostic scoring model, which considered the numbers ofinvolved lymph nodes as the rate of significance according to the location, may moreprecisely predict the survival outcome in patients with lymph node metastasis.

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