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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제43권 제4호
발행연도
2011.1
수록면
236 - 243 (8page)

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Purpose The aims of this study are to find out whether the sequence of chemotherapeutic regimens including second- and third-line taxane and irinotecan influences the survival of patients with unresectable gastric carcinoma and to identify clinical characteristics of patients with improved response. Materials and Methods Fifty gastric carcinoma patients who were treated by third-line sequential chemotherapy between November 2004 and July 2010 were enrolled in this study. Their overall survival (OS) and time to progression (TTP) were set up as primary and secondary end points. For the sequence of chemotherapy regimen, two arms were used. Arm A was defined as 5-fluorouracil (5-FU)+cisplatin (FP) or folinic acid, 5-FU and oxaliplati (FOLFOX), followed by folinic acid, 5-FU and irinotecan (FOLFIRI), and paclitaxel or docetaxel plus 5-FU, with or without epirubicin. Arm B was defined as FP or FOLFOX, followed by paclitaxel or docetaxel plus 5-FU, and FOLFIRI. Results The median OS of all patients was 16.0 months (95% confidence interval, 13.6 to 18.3 months),which is longer than historical control of patients who did not receive third-line chemotherapy. The sequence of second and third-line regimen, including irinotecan and taxane, did not present significant difference in OS or TTP after failure of 5-FU with platinum chemotherapy. In survival analysis of patients’ clinicopathologic characteristics, poor prognosis was shown in patients with poorly differentiated histologic features, elevated serum carcinoembryonic level, and shorter TTP of first line chemotherapy. Conclusion It is possible for patients to respond differently to chemotherapy due to differences in clinical features and underlying gene expression profiles. Development of individualized chemotherapy regimens based on gene expression profiles is warranted.
#Stomach neoplasms #Salvage therapy #Prognosis #Oxaliplatin #Irinotecan #Taxane

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참고문헌 (25)

참고문헌 신청
Ueda K / 2001 / Carcinoembryonic antigen-specific suicide gene therapy of cytosine deaminase/5-fluorocytosine enhanced by the cre/loxP system in the orthotopic gastric carcinoma model / Cancer Res 61:6158~6162 google schola Toffoli G / 2007 / Clinical implications of genetic polymorphisms on stomach cancer drug therapy / Pharmacogenomics J 7:76~80 google schola Golub TR / 1999 / Molecular classification of cancer: class discovery and class prediction by gene expression monitoring / Science 286:531~537 google schola / 200809 / Irinotecan combined with 5-fluorouracil and leucovorin as second-line chemotherapy for metastatic or relapsed gastric cancer / JAPANESE JOURNAL OF CLINICAL ONCOLO google schola Ajani JA / 2005 / Evolving chemotherapy for advanced gastric cancer / Oncologist 10 (3) : 49 ~ 58 google schola

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