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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 122 - 128 (7page)
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초록· 키워드
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Purpose: Histone deacetylase inhibitors (HDIs) are emerging as potentially useful components in anticancer therapy. In this study, we tried to confirm the radiosensitizing effect of richostatin A (TSA) on a panel of uman carcinoma cell lines and elucidate its mechanism of interaction.
Materials and Methods: A549, HeLa and Caski cells were exposed to TSA for 18 hr prior to irradiation, and the cell survival then measured using a clonogenic assay. Western blot and flow cytometric analyses, for histone acetylation, and cell cycle and apoptosis, respectively,were also performed.
Results: TSA increased the acetylation of histone H3. The pretreatment of TSA consistently radiosensitized all three cell lines. The SF2 (surviving fraction at 2 Gy) of TSA-treated cells was significantly lower than that of mock treated cells. The SER (sensitizer enhancement ratio) increased in all 3 cell lines, in concentration dependent manners. The TSA treated cells showed abrogation of radiation-induced G2/M arrest, in a concentration dependent manner.
Conclusion: The pretreatment of TSA enhanced the radiosensitivity of a panel of human carcinoma cells, which was attributed, in part, to the abrogation of radiationinduced G2/M arrest.
목차
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참고문헌 (25)
참고문헌 신청
/ 1985 / Enhancement of radiation injury in human colon tumor cells by the maturational agent sodium butyrate : 443 ~ 8
/ 1993 / Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/ or simian virus 40T-antigen 133 : 73 ~ 9
/ 1996 / The expression of small fraction of cellular genes is changed in response to histone hyperacetylation 5 : 245 ~ 53
/ 1997 / Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors 53 : 1357 ~ 68
/ 1997 / Histone acetylation and chromatin structure and transcription 389 : 349 ~ 52
/ 1993 / Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/ or simian virus 40T-antigen 133 : 73 ~ 9
/ 1996 / The expression of small fraction of cellular genes is changed in response to histone hyperacetylation 5 : 245 ~ 53
/ 1997 / Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors 53 : 1357 ~ 68
/ 1997 / Histone acetylation and chromatin structure and transcription 389 : 349 ~ 52
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